Role of IL-6 and IL-6 targeted therapy in systemic lupus erythematosus

被引：8
作者：
Nepal, Desh [1 ,2 ]
Gazeley, David [1 ]
机构：
[1] Med Coll Wisconsin, Dept Med, Div Rheumatol, Milwaukee, WI USA
[2] Med Coll Wisconsin, Rheumatol, Hub Collaborat Med, 8701 Watertown Plan Rd,6th Floor, Milwaukee, WI 53226 USA
来源：
RHEUMATOLOGY | 2023年 / 62卷 / 12期
关键词：
IL-6; inhibition; SLE; tocilizumab; sirukumab; OF-RHEUMATOLOGY GUIDELINE; PHASE PROTEIN RESPONSE; MONOCLONAL-ANTIBODY; DISEASE-ACTIVITY; MURINE LUPUS; T-CELLS; INTERLEUKIN-6; TOCILIZUMAB; EFFICACY; RECEPTOR;
D O I：
10.1093/rheumatology/kead416
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interleukin-6 is one of the cytokines implicated in murine and human SLE. Only a few small studies have investigated IL-6 inhibition in human SLE. Currently, there are no studies registered in clinicaltrials.gov to assess the IL-6 targeted therapy in SLE, yet its role in the future remains to be defined. This narrative review analyses these and potential areas of future studies with IL-6 targeted therapy in SLE. A video abstract is available for this article and can be viewed at https://doi.org/10.1093/rheumatology/kead416.
引用
收藏
页码：3804 / 3810
页数：7
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