Role of IL-6 and IL-6 targeted therapy in systemic lupus erythematosus

被引：8
作者：
Nepal, Desh [1 ,2 ]
Gazeley, David [1 ]
机构：
[1] Med Coll Wisconsin, Dept Med, Div Rheumatol, Milwaukee, WI USA
[2] Med Coll Wisconsin, Rheumatol, Hub Collaborat Med, 8701 Watertown Plan Rd,6th Floor, Milwaukee, WI 53226 USA
来源：
RHEUMATOLOGY | 2023年 / 62卷 / 12期
关键词：
IL-6; inhibition; SLE; tocilizumab; sirukumab; OF-RHEUMATOLOGY GUIDELINE; PHASE PROTEIN RESPONSE; MONOCLONAL-ANTIBODY; DISEASE-ACTIVITY; MURINE LUPUS; T-CELLS; INTERLEUKIN-6; TOCILIZUMAB; EFFICACY; RECEPTOR;
D O I：
10.1093/rheumatology/kead416
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interleukin-6 is one of the cytokines implicated in murine and human SLE. Only a few small studies have investigated IL-6 inhibition in human SLE. Currently, there are no studies registered in clinicaltrials.gov to assess the IL-6 targeted therapy in SLE, yet its role in the future remains to be defined. This narrative review analyses these and potential areas of future studies with IL-6 targeted therapy in SLE. A video abstract is available for this article and can be viewed at https://doi.org/10.1093/rheumatology/kead416.
引用
收藏
页码：3804 / 3810
页数：7
相关论文
共 50 条
  • [31] SERUM-SOLUBLE INTERLEUKIN-6 (IL-6) RECEPTOR AND IL-6 SOLUBLE IL-6 RECEPTOR COMPLEX IN SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS
    DEBENEDETTI, F
    MASSA, M
    PIGNATTI, P
    ALBANI, S
    NOVICK, D
    MARTINI, A
    JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (05) : 2114 - 2119
  • [32] IL-6 blockers in systemic onset juvenile idiopathic arthritis
    Barone, Patrizia
    Pignataro, Rossana
    Garozzo, Maria Teresa
    Leonardi, Salvatore
    IMMUNOTHERAPY, 2016, 8 (01) : 79 - 87
  • [33] Local and systemic effects of interleukin-6 (IL-6) in inflammation and cancer
    Rose-John, Stefan
    FEBS LETTERS, 2022, 596 (05) : 557 - 566
  • [34] Peripheral blood IL-6 levels in systemic sclerosis patients: Correlation between IL-6 levels and clinical phenotypes
    Lin, Xiao
    Ding, Mingming
    Chen, Tan
    Min, Shuhui
    Wang, Danfeng
    Jiang, Guan
    JOURNAL OF COSMETIC DERMATOLOGY, 2022, 21 (11) : 6086 - 6091
  • [35] The influence of systemic therapy on the serum levels of IL-6 and IL-8 in pemphigus vulgaris
    Mortazavi, H.
    Babaeijandaghi, F.
    Akbarzadeh, M.
    Rezaei, N.
    Amirzargar, A. A.
    Daneshpazhooh, M.
    Jalali, A.
    Hallaji, Z.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2013, 27 (03) : 387 - 390
  • [36] Inhibition of inflammation by IL-6 blockade in xenotransplantation
    Iwanczyk, Zuzanna
    Hara, Hidetaka
    Cooper, David K. C.
    Maenaka, Akihiro
    CYTOKINE, 2025, 189
  • [37] Role of IL-6 in dendritic cell functions
    Xu, Yu-Dong
    Cheng, Mi
    Shang, Pan-Pan
    Yang, Yong-Qing
    JOURNAL OF LEUKOCYTE BIOLOGY, 2022, 111 (03) : 695 - 709
  • [38] IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
    Kaminska, Joanna
    Dymicka-Piekarska, Violetta
    Chrzanowski, Robert
    Sawicki, Karol
    Milewska, Anna J.
    Zinczuk, Justyna
    Tylicka, Marzena
    Jadeszko, Marek
    Mariak, Zenon
    Kratz, Ewa M.
    Matowicka-Karna, Joanna
    Kornhuber, Johannes
    Lewczuk, Piotr
    Koper-Lenkiewicz, Olga M.
    JOURNAL OF INFLAMMATION RESEARCH, 2021, 14 : 6103 - 6114
  • [39] The role of the interleukin (IL)-6/IL-6 receptor axis in cancer
    Taher, Mustafa Yassin
    Davies, David Marc
    Maher, John
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2018, 46 : 1449 - 1462
  • [40] IL-6 receptor expression and IL-6 effects change during osteoblast differentiation
    Li, Yan
    Bakesjo, Carl-Magnus
    Haldosen, Lars-Arne
    Lindgren, Urban
    CYTOKINE, 2008, 43 (02) : 165 - 173
12345