Highly piezoelectric, biodegradable, and flexible amino acid nanofibers for medical applications

被引:78
作者
Chorsi, Meysam T. [1 ,2 ]
Le, Thinh T. [1 ]
Lin, Feng [1 ]
Vinikoor, Tra [2 ]
Das, Ritopa [2 ]
Stevens, James F. [1 ]
Mundrane, Caitlyn [2 ]
Park, Jinyoung [2 ]
Tran, Khanh T. M. [2 ]
Liu, Yang [1 ,6 ]
Pfund, Jacob [3 ]
Thompson, Rachel [2 ]
He, Wu [4 ]
Jain, Menka [3 ,5 ]
Morales-Acosta, M. Daniela [5 ]
Bilal, Osama R. [1 ]
Kazerounian, Kazem [1 ,2 ]
Ilies, Horea [1 ]
Nguyen, Thanh D. [1 ,2 ,5 ]
机构
[1] Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA
[2] Univ Connecticut, Dept Biomed Engn, Storrs, CT 06269 USA
[3] Univ Connecticut, Dept Phys, Storrs, CT 06269 USA
[4] Univ Connecticut, Ctr Open Res Resources & Equipment, Flow Cytometry Facil, Storrs, CT 06269 USA
[5] Univ Connecticut, Inst Mat Sci, Storrs, CT 06269 USA
[6] Peking Univ, Sch & Hosp Stomatol, Ctr Digital Dent, Ctr Oral Biomat & Digital Med Devices,Dept Prostho, Beijing 100081, Peoples R China
关键词
MECHANICAL-PROPERTIES; NIOBIUM; ULTRASOUND; NANOGENERATORS; ZIRCONIUM; TOXICITY; ANTIMONY; GROWTH; ENERGY; FILMS;
D O I
10.1126/sciadv.adg6075
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Amino acid crystals are an attractive piezoelectric material as they have an ultrahigh piezoelectric coefficient and have an appealing safety profile for medical implant applications. Unfortunately, solvent-cast films made from glycine crystals are brittle, quickly dissolve in body fluid, and lack crystal orientation control, reducing the overall piezoelectric effect. Here, we present a material processing strategy to create biodegradable, flexible, and piezoelectric nanofibers of glycine crystals embedded inside polycaprolactone (PCL). The glycine-PCL nanofiber film exhibits stable piezoelectric performance with a high ultrasound output of 334 kPa [under 0.15 voltage root-mean-square (Vrms)], which outperforms the state-of-the-art biodegradable transducers. We use this material to fabricate a biodegradable ultrasound transducer for facilitating the delivery of chemotherapeutic drug to the brain. The device remarkably enhances the animal survival time (twofold) in mice-bearing orthotopic glioblastoma models. The piezoelectric glycine-PCL presented here could offer an excellent platform not only for glioblastoma therapy but also for developing medical implantation fields.
引用
收藏
页数:18
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共 78 条
[1]   The blood-brain barrier and blood-tumour barrier in brain tumours and metastases [J].
Arvanitis, Costas D. ;
Ferraro, Gino B. ;
Jain, Rakesh K. .
NATURE REVIEWS CANCER, 2020, 20 (01) :26-41
[2]   Anisotropic PCL nanofibers embedded with nonlinear nanocrystals as strong generators of polarized second harmonic light and piezoelectric currents [J].
Bernardo, Cesar R. ;
Baptista, Rosa M. F. ;
Gomes, Etelvina de Matos ;
Lopes, Paulo E. ;
Raposo, Maria Manuela M. ;
Costa, Susana P. G. ;
Belsley, Michael S. .
NANOSCALE ADVANCES, 2020, 2 (03) :1206-1213
[3]   Amino acids nanocrystals for piezoelectric detection of ultra-low mechanical pressure [J].
Bishara, Hanna ;
Nagel, Alina ;
Levanon, Maya ;
Berger, Shlomo .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 108
[4]   Clinical trial of blood-brain barrier disruption by pulsed ultrasound [J].
Carpentier, Alexandre ;
Canney, Michael ;
Vignot, Alexandre ;
Reina, Vincent ;
Beccaria, Kevin ;
Horodyckid, Catherine ;
Karachi, Carine ;
Leclercq, Delphine ;
Lafon, Cyril ;
Chapelon, Jean-Yves ;
Capelle, Laurent ;
Cornu, Philippe ;
Sanson, Marc ;
Hoang-Xuan, Khe ;
Delattre, Jean-Yves ;
Idbaih, Ahmed .
SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (343)
[5]   Piezoelectric Nanogenerator Based on In Situ Growth All-Inorganic CsPbBr3 Perovskite Nanocrystals in PVDF Fibers with Long-Term Stability [J].
Chen, Huiying ;
Zhou, Linlin ;
Fang, Zhi ;
Wang, Shuize ;
Yang, Tao ;
Zhu, Laipan ;
Hou, Xinmei ;
Wang, Hailong ;
Wang, Zhong Lin .
ADVANCED FUNCTIONAL MATERIALS, 2021, 31 (19)
[6]   Wirelessly Powered Electrical-Stimulation Based on Biodegradable 3D Piezoelectric Scaffolds Promotes the Spinal Cord Injury [J].
Chen, Ping ;
Xu, Chao ;
Wu, Ping ;
Liu, Kun ;
Chen, Feixiang ;
Chen, Yun ;
Dai, Honglian ;
Luo, Zhiqiang .
ACS NANO, 2022, 16 (10) :16513-16528
[7]   Microstructures and piezoelectric performance of eco-friendly composite films based on nanocellulose and barium titanate nanoparticle [J].
Choi, Hyeong Yeol ;
Jeong, Young Gyu .
COMPOSITES PART B-ENGINEERING, 2019, 168 :58-65
[8]  
Chorsi M. T., 2021, ADV ROBOT KINEMATICS, P41
[9]   Piezoelectric Biomaterials for Sensors and Actuators [J].
Chorsi, Meysam T. ;
Curry, Eli J. ;
Chorsi, Hamid T. ;
Das, Ritopa ;
Baroody, Jeffrey ;
Purohit, Prashant K. ;
Ilies, Horea ;
Nguyen, Thanh D. .
ADVANCED MATERIALS, 2019, 31 (01)
[10]   Biodegradable nanofiber-based piezoelectric transducer [J].
Curry, Eli J. ;
Le, Thinh T. ;
Das, Ritopa ;
Ke, Kai ;
Santorella, Elise M. ;
Paul, Debayon ;
Chorsi, Meysam T. ;
Tran, Khanh T. M. ;
Baroody, Jeffrey ;
Borges, Emily R. ;
Ko, Brian ;
Golabchi, Asiyeh ;
Xin, Xiaonan ;
Rowe, David ;
Yue, Lixia ;
Feng, Jianlin ;
Morales-Acosta, M. Daniela ;
Wu, Qian ;
Chen, I-Ping ;
Cui, X. Tracy ;
Pachter, Joel ;
Nguyen, Thanh D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (01) :214-220