The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome-An rTMS Study

被引：3
作者：
Paulus, Theresa [1 ,2 ]
Wernecke, Lynn [1 ]
Lundie, Annik [1 ]
Friedrich, Julia [1 ]
Verrel, Julius [1 ]
Rawish, Tina [1 ]
Weissbach, Anne [1 ,3 ]
Frings, Christian [4 ]
Beste, Christian [5 ,6 ,7 ]
Baeumer, Tobias [1 ]
Muenchau, Alexander [1 ]
机构：
[1] Univ Lubeck, Inst Syst Motor Sci, D-23562 Lubeck, Germany
[2] Univ Lubeck, Dept Neurol, D-23562 Lubeck, Germany
[3] Univ Lubeck, Inst Neurogenet, D-23562 Lubeck, Germany
[4] Univ Trier, Fac Psychol, Dept Cognit Psychol, D-54296 Trier, Germany
[5] Tech Univ Dresden, Fac Med, Dept Child & Adolescent Psychiat, Cognit Neurophysiol, D-01307 Dresden, Germany
[6] Tech Univ Dresden, Fac Med, Neuropsychol Ctr, D-01307 Dresden, Germany
[7] Shandong Normal Univ, Fac Psychol, Cognit Psychol, Jinan 250014, Peoples R China
来源：
BIOMEDICINES | 2023年 / 11卷 / 03期
关键词：
Gilles de la Tourette syndrome; tics; repetitive transcranial magnetic stimulation; left inferior parietal cortex; BA40; rush score; TRANSCRANIAL MAGNETIC STIMULATION; SUPPLEMENTARY MOTOR AREA; SCALE; TICS; EXCITABILITY; VALIDATION; BRAIN;
D O I：
10.3390/biomedicines11030980
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in the Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigated the immediate effects of single-session 1 Hz rTMS and sham stimulation delivered to the left BA40 on tics assessed with the Rush video protocol in 29 adults with GTS. There were no significant effects on tic symptoms following rTMS or sham stimulation. Moreover, there was no difference when comparing the effects of both stimulation conditions. Bayesian statistics indicated substantial evidence against an intervention effect. The left BA40 appears not to be a useful target for 1 Hz rTMS to modulate tic symptoms in GTS patients.
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收藏
页数：9
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