An optical design enabling lightweight and large field-of-view head-mounted microscopes

被引：17

作者：

Scherrer, Joseph R. R. ^{[1
]}

Lynch, Galen F. F. ^{[1
]}

Zhang, Jie J. J. ^{[1
]}

Fee, Michale S. S. ^{[1
]}

机构：

[1] MIT, McGovern Inst Brain Res, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

来源：

NATURE METHODS | 2023年 / 20卷 / 04期

关键词：

D O I：

10.1038/s41592-023-01806-1

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we present a fluorescence microscope light path that enables imaging, during free behavior, of thousands of neurons in mice and hundreds of neurons in juvenile songbirds. The light path eliminates traditional illumination optics, allowing for head-mounted microscopes that have both a lower weight and a larger field of view (FOV) than previously possible. Using this light path, we designed two microscopes: one optimized for FOV (similar to 4 mm FOV; 1.4 g), and the other optimized for weight (1.0 mm FOV; 1.0 g).

引用

页码：546 / 549

页数：20

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