The SAFER (Simple Algorithm for Evapotranspiration Retrieving) algorithm was applied to test water balance (WB) monitoring in the agricultural growing region of SEALBA, an acronym for the states Sergipe (SE), Alagoas (AL), and Bahia (BA), coastal Northeast Brazil, classifying the biomes Atlantic Forest and Caatinga. The MODIS MOD13Q1 reflectance product and meteorological data were used to calculate actual (ET) and reference (ET0) evapotranspiration at 16-day timescale along the years 2007-2021. The period with the highest precipitation (P) is in May, when the 16 day values are above 90 mm in Atlantic Forest and higher than 70 mm in Caatinga. For ET, the largest rates occur between July and September, when the 16-day average surpass 2.70 mm d-1 in the Atlantic Forest and 2.90 mm d-1 in Caatinga. Larger P together with lower ET, concentrates the positive water balance WB (P - ET) from March to August in both biomes, bringing suitability for the rainfed agriculture. However, from July to December occur the negative WB values, indicating the need of irrigation for critical crop stages. Inferring the root-zone moisture conditions throughout the evaporative fraction values (ETf = ET/ET0) it is noticed that their highest values occur from April to October, evidencing a delay between the moment in which rainfall attend evapotranspiration with that in which the root-zone moisture recovers the optimum levels after the driest periods, what was also confirmed by the Pearson correlation coefficient values. The large-scale modelling carried out in SEALBA, presented viability to subsidize public policies regarding the water resources, with potential for replication of the methods in other regions.