A comprehensive meta-analysis to identify susceptibility genetic variants for precocious puberty

被引:2
|
作者
Gu, Xiuli [1 ]
Xiong, Weining [2 ]
Yang, Yan [1 ]
Li, Honggang [3 ]
Xiong, Chengliang [1 ]
机构
[1] Wuhan Huake Reprod Hosp, Sangyang Rd 128, Wuhan 430013, Peoples R China
[2] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Dept Biol Sci & Technol, Wuhan, Peoples R China
[3] Huazhong Univ Sci & Technol, Inst Reprod Hlth, Tongji Med Coll, Wuhan, Peoples R China
关键词
genetic susceptibility; meta-analysis; precocious puberty; variant; RECEPTOR-ALPHA GENE; ESTROGEN-RECEPTOR; KISS1; GENE; KOREAN GIRLS; POLYMORPHISMS; ASSOCIATION; LIN28B; LOCALIZATION; MKRN3;
D O I
10.1111/ahg.12525
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Purpose: Currently, several genetic variants in ER alpha gene (rs2234693 and rs9340799), ER beta gene (rs1256049 and rs4986938), KISS1 gene (rs4889, rs1132506 and rs5780218), LIN28B gene (rs314263, rs314276 and rs314280), and MKRN3 gene (rs2239669) have been repeatedly explored for their contribution to precocious puberty (PP) susceptibility. However, the results remain conflicting rather than conclusive. We here performed a meta-analysis to identify the real susceptibility genetic variants for PP.Methods: After screening by inclusion criteria, 20 related studies were finally included in this meta-analysis. The odds ratios and 95% confidence intervals were calculated to assess the strength of association. Sensitive analysis, publication bias, and trial sequential analysis (TSA) were performed to evaluate the stability and reliability of results.Results: Rs2234693, rs9340799, and rs1256049 were significantly associated with PP susceptibility (p < 0.0084). Stratified analysis according to ethnicity showed that rs2234693 and rs9340799 were significantly associated with PP susceptibility in Asian and Chinese populations. Stratified analysis according to PP subtype showed that rs2234693 and rs9340799 were significantly associated with idiopathic central PP susceptibility in Asian and Chinese populations (p < 0.0084). The results of publication bias, sensitivity analysis, and TSA provided solid evidence for the association between these three variants and PP susceptibility.Conclusions: Rs2234693 and rs9340799 in ER alpha gene and rs1256049 in ER beta gene may serve as susceptive factors for PP development. The present finding should be confirmed in replication studies and reinforced in functional studies, which will ultimately improve the feasibility of the application of these three PP-susceptible loci in clinical practice.
引用
收藏
页码:138 / 153
页数:16
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