Semi-Automated Analysis of Foveal Maturity in Premature and Full-Term Infants Using Handheld Swept-Source Optical Coherence Tomography

被引：6

作者：

Lawson, Sumner E. ^{[1
]}

Tam, Emily K. ^{[2
,3
]}

Zheng, Yujiao ^{[4
]}

Liu, Teng ^{[4
]}

Monger, Tatiana R. ^{[2
]}

Lee, Karen E. ^{[5
]}

Legocki, Alex ^{[3
]}

Kelly, John ^{[2
]}

Ding, Leona ^{[3
]}

Wang, Ruikang K. ^{[3
,4
]}

Tarczy-Hornoch, Kristina ^{[2
,3
]}

Cabrera, Michelle T. ^{[2
,3
,6
]}

机构：

[1] Univ Washington, Sch Med, Seattle, WA USA

[2] Seattle Childrens Hosp, Div Ophthalmol, Seattle, WA USA

[3] Univ Washington, Dept Ophthalmol, Seattle, WA USA

[4] Univ Washington, Dept Bioengn, Seattle, WA USA

[5] Wills Eye Hosp & Res Inst, Pediat Ophthalmol Serv, Philadelphia, PA USA

[6] OA 9 220 Ophthalmol,4800 Sand Point Way NE, Seattle, WA 98105 USA

来源：

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY | 2023年 / 12卷 / 03期

基金：

美国国家卫生研究院;

关键词：

foveal development; optical coherence tomography (OCT); retinopathy of prematurity; RETINOPATHY; PRETERM; THICKNESS; CHILDREN; HISTORY; BIRTH; PIT;

D O I：

10.1167/tvst.12.3.5

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To develop a semi-automated method of measuring foveal maturity using investigational handheld swept source-optical coherence tomography (SS-OCT).Methods: In this prospective, observational study, full-term newborns and preterm infants undergoing routine retinopathy of prematurity screening were imaged. Semi -automated analysis measured foveal angle and chorioretinal thicknesses at the central fovea and average two-sided parafovea by three-grader consensus, correlating with OCT features and demographics.Results: One hundred ninety-four imaging sessions from 70 infants were included (47.8% girls, 37.6 & PLUSMN; 3.4 weeks postmenstrual age, 26 preterm infants with birth weight 1057 & PLUSMN; 325.0, gestational age 29.0 & PLUSMN; 3.0 weeks). Foveal angle (96.1 & PLUSMN; 22.0 degrees) steepened with increasing birth weight (P = 0.003), decreasing inner retinal layer thick-ness, and increasing gestational age, postmenstrual age, and foveal and parafoveal choroidal thickness (all P < 0.001). Inner retinal fovea/parafovea ratio (0.4 & PLUSMN; 0.2) corre-lated with increasing inner foveal layers, decreasing postmenstrual age, gestational age, and birth weight (all P < 0.001). Outer retinal F/P ratio (0.7 & PLUSMN; 0.2) correlated with ellip-soid zone presence (P < 0.001), increased gestational age (P = 0.002), and birth weight (P = 0.003). Foveal (447.8 & PLUSMN; 120.6 microns) and parafoveal (420.9 & PLUSMN; 109.2) choroidal thicknesses correlated with foveal ellipsoid zone presence (P = 0.007 and P = 0.01, respectively), postmenstrual age, birth weight, gestational age, and decreasing inner retinal layers (all P < 0.001).Conclusions: Foveal development is dynamic and partially observed through semi-automated analysis of handheld SS-OCT imaging. Translational Relevance: Semi-automated analysis of SS-OCT images can identify measures of foveal maturity.

引用

页数：9

共 24 条

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