Vinculin B inhibits NF-KB signaling pathway by targeting MyD88 in miiuy croaker, Miichthys miiuy

被引：1

作者：

Cao, Baolan ^{[1
]}

Zhao, Yan ^{[1
]}

Luo, Qiang ^{[1
]}

Chen, Ya ^{[1
]}

Xu, Tianjun ^{[1
,2
]}

Sun, Yuena ^{[1
,3
,4
]}

机构：

[1] Shanghai Ocean Univ, Coll Fisheries & Life Sci, Lab Fish Mol Immunol, Shanghai, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China

[3] Shanghai Ocean Univ, Natl Pathogen Collect Ctr Aquat Anim, Shanghai, Peoples R China

[4] Shanghai Ocean Univ, Minist Agr & Rural Affairs, Key Lab Freshwater Aquat Genet Resources, Shanghai, Peoples R China

来源：

FISH & SHELLFISH IMMUNOLOGY | 2023年 / 135卷

关键词：

MyD88; Vclb; Ubiquitin-proteasome pathway; Innate immune; NF-KB; TOLL-LIKE RECEPTORS; INFLAMMATORY RESPONSE; NEGATIVE REGULATOR; ADAPTER PROTEIN; GENE-EXPRESSION; TELEOST FISH; ACTIVATION; INNATE; DYNAMICS; IMMUNITY;

D O I：

10.1016/j.fsi.2023.108683

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

Myeloid differentiation factor 88 (MyD88) is the canonical adaptor for inflammatory signaling pathways downstream from members of the Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor families, which activates the NF-KB signaling pathway and regulates immune and inflammatory responses. In this study, we found that Vinculin B (Vclb) is an inhibitor in the NF-KB signaling pathway, and its inhibitory effect was enhanced by LPS induction. Furthermore, Vclb inhibits NF-KB activation by targeting MyD88, thereby suppressing the production of inflammatory cytokines. Mechanistically, Vclb inhibits the NF-KB signaling pathway by targeting MyD88 ubiquitin-proteasome pathway. In summary, our study reveals that Vclb inhibits NF-KB signaling activation and mediates innate immunity in teleosts via the ubiquitin-proteasome pathway of MyD88.

引用

页数：9

共 57 条

[1]

BELKIN AM, 1988, J BIOL CHEM, V263, P6631

[2] Ubiquitin proteasome system in immune regulation and therapeutics [J].

Bhat, Sameer Ahmed ;

Vasi, Zahra ;

Adhikari, Ritika ;

Gudur, Anish ;

Ali, Asceal ;

Jiang, Liping ;

Ferguson, Rachel ;

Liang, David ;

Kuchay, Shafi .

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 2022, 61

[3] Zw10 negatively regulates the MyD88-mediated NF-xB signaling through autophagy in teleost fish [J].

Cao, Baolan ;

Chen, Ya ;

Cui, Junxia ;

Sun, Yuena ;

Xu, Tianjun .

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2022, 132

[4] Vinculin, an adapter protein in control of cell adhesion signalling [J].

Carisey, Alex ;

Ballestrem, Christoph .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2011, 90 (2-3) :157-163

[5] The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation [J].

Chen, Rui ;

Li, Mi ;

Zhang, Yu ;

Zhou, Qian ;

Shu, Hong-Bing .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (35) :14128-14133

[6] Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) in fish: current knowledge and future perspectives [J].

Chen, Shan Nan ;

Zou, Peng Fei ;

Nie, Pin .

IMMUNOLOGY, 2017, 151 (01) :16-25

[7] eIF3k inhibits NF-κB signaling by targeting MyD88 for ATG5-mediated autophagic degradation in teleost fish [J].

Chen, Ya ;

Cao, Baolan ;

Zheng, Weiwei ;

Sun, Yuena ;

Xu, Tianjun .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 298 (03)

[8] Vinculin b deficiency causes epicardial hyperplasia and coronary vessel disorganization in zebrafish [J].

Cheng, Feng ;

Miao, Liyun ;

Wu, Qing ;

Gong, Xia ;

Xiong, Jingwei ;

Zhang, Jian .

DEVELOPMENT, 2016, 143 (19) :3522-3531

[9] MicroRNA-148 as a negative regulator of the common TLR adaptor mediates inflammatory response in teleost fish [J].

Chu, Qing ;

Gao, Yunhang ;

Bi, Dekun ;

Xu, Tianjun .

SCIENTIFIC REPORTS, 2017, 7

[10] MicroRNA-3570 Modulates the NF-κB Pathway in Teleost Fish by Targeting MyD88 [J].

Chu, Qing ;

Sun, Yuena ;

Cui, Junxia ;

Xu, Tianjun .

JOURNAL OF IMMUNOLOGY, 2017, 198 (08) :3274-3282

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