CNS-peripheral immune interactions in hemorrhagic stroke

被引：34
作者：
Li, Xiang [1 ,2 ,3 ]
Chen, Gang [1 ,2 ,3 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg & Brain, Suzhou 215006, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Brain & Nerve Res Lab, Suzhou 215006, Peoples R China
[3] Soochow Univ, Inst Stroke Res, Suzhou, Peoples R China
来源：
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2023年 / 43卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Systemic inflammation; stroke; intracerebral hemorrhage; subarachnoid hemorrhage; immune dysregulation; REGULATORY T-CELLS; EXPERIMENTAL INTRACEREBRAL HEMORRHAGE; BLOOD-BRAIN-BARRIER; SUBARACHNOID HEMORRHAGE; INFLAMMATORY INJURY; ISCHEMIC-STROKE; SPLENIC ATROPHY; MICROGLIA; MECHANISMS; POLARIZATION;
D O I：
10.1177/0271678X221145089
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Stroke is a sudden and rapidly progressing ischemic or hemorrhagic cerebrovascular disease. When stroke damages the brain, the immune system becomes hyperactive, leading to systemic inflammatory response and immunomodulatory disorders, which could significantly impact brain damage, recovery, and prognosis of stroke. Emerging researches suggest that ischemic stroke-induced spleen contraction could activate a peripheral immune response, which may further aggravate brain injury. This review focuses on hemorrhagic strokes including intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) and discusses the central nervous system-peripheral immune interactions after hemorrhagic stroke induction. First, inflammatory progression after ICH and SAH is investigated. As a part of this review, we summarize the various kinds of inflammatory cell infiltration to aggravate brain injury after blood-brain barrier interruption induced by hemorrhagic stroke. Then, we explore hemorrhagic stroke-induced systemic inflammatory response syndrome (SIRS) and discuss the interactions of CNS and peripheral inflammatory response. In addition, potential targets related to inflammatory response for ICH and SAH are discussed in this review, which may lead to novel therapeutic strategies for hemorrhagic stroke.
引用
收藏
页码：185 / 197
页数：13
相关论文
共 144 条
[81]   A Transient Decrease in Spleen Size Following Stroke Corresponds to Splenocyte Release into Systemic Circulation [J].
Seifert, Hilary A. ;
Hall, Aaron A. ;
Chapman, Cortney B. ;
Collier, Lisa A. ;
Willing, Alison E. ;
Pennypacker, Keith R. .
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2012, 7 (04) :1017-1024
[82]   At the Intersection of Gut Microbiome and Stroke: A Systematic Review of the Literature [J].
Sharma, Vishakha ;
Sharma, Vaibhav ;
Shahjouei, Shima ;
Li, Jiang ;
Chaudhary, Durgesh ;
Khan, Ayesha ;
Wolk, Donna M. ;
Zand, Ramin ;
Abedi, Vida .
FRONTIERS IN NEUROLOGY, 2021, 12
[83]   Targeting the Immune System in Intracerebral Hemorrhage [J].
Sheth, Kevin N. ;
Rosand, Jonathan .
JAMA NEUROLOGY, 2014, 71 (09) :1083-1084
[84]   IL (Interleukin)-15 Bridges Astrocyte-Microglia Crosstalk and Exacerbates Brain Injury Following Intracerebral Hemorrhage [J].
Shi, Samuel X. ;
Li, Yu-Jing ;
Shi, Kaibin ;
Wood, Kristofer ;
Ducruet, Andrew F. ;
Liu, Qiang .
STROKE, 2020, 51 (03) :967-974
[85]   Stroke subtype-dependent synapse elimination by reactive gliosis in mice [J].
Shi, Xiaojing ;
Luo, Longlong ;
Wang, Jixian ;
Shen, Hui ;
Li, Yongfang ;
Mamtilahun, Muyassar ;
Liu, Chang ;
Shi, Rubing ;
Lee, Joon-Hyuk ;
Tian, Hengli ;
Zhang, Zhijun ;
Wang, Yongting ;
Chung, Won-Suk ;
Tang, Yaohui ;
Yang, Guo-Yuan .
NATURE COMMUNICATIONS, 2021, 12 (01)
[86]   Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation [J].
Shinozaki, Youichi ;
Shibata, Keisuke ;
Yoshida, Keitaro ;
Shigetomi, Eiji ;
Gachet, Christian ;
Ikenaka, Kazuhiro ;
Tanaka, Kenji F. ;
Koizumi, Schuichi .
CELL REPORTS, 2017, 19 (06) :1151-1164
[87]   Interaction between the hypothalamus and the immune system [J].
Soto-Tinoco, Eva ;
Guerrero-Vargas, Natali N. ;
Buijs, Ruud M. .
EXPERIMENTAL PHYSIOLOGY, 2016, 101 (12) :1463-1471
[88]   The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes [J].
Stamova, Boryana ;
Ander, Bradley P. ;
Jickling, Glen ;
Hamade, Farah ;
Durocher, Marc ;
Zhan, Xinhua ;
Liu, Da Zhi ;
Cheng, Xiyuan ;
Hull, Heather ;
Yee, Alan ;
Ng, Kwan ;
Shroff, Natasha ;
Sharp, Frank R. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 (09) :1818-1835
[89]   RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury [J].
Stern, Sina ;
Hilton, Brett J. ;
Burnside, Emily R. ;
Dupraz, Sebastian ;
Handley, Emily E. ;
Gonyer, Jessica M. ;
Brakebusch, Cord ;
Bradke, Frank .
NEURON, 2021, 109 (21) :3436-+
[90]   Early release of high-mobility group box 1 (HMGB1) from neurons in experimental subarachnoid hemorrhage in vivo and in vitro [J].
Sun, Qing ;
Wu, Wei ;
Hu, Yang-Chun ;
Li, Hua ;
Zhang, Dingding ;
Li, Song ;
Li, Wei ;
Li, Wei-De ;
Ma, Biao ;
Zhu, Jian-Hong ;
Zhou, Meng-Liang ;
Hang, Chun-Hua .
JOURNAL OF NEUROINFLAMMATION, 2014, 11
45678910111213