Molecular characterization of the meq oncogene of Marek's disease virus in vaccinated Brazilian poultry farms reveals selective pressure on prevalent strains

被引：6

作者：

Chacon, Ruy D. ^{[1
]}

Sanchez-Llatas, Christian J. ^{[2
]}

L. Pajuelo, Sarah ^{[3
]}

Diaz Forero, Andrea J. ^{[1
]}

Jimenez-Vasquez, Victor ^{[4
]}

Medico, Jack A. ^{[5
]}

Soto-Ugaldi, Luis F. ^{[6
]}

Astolfi-Ferreira, Claudete S. ^{[1
]}

Piantino Ferreira, Antonio J. ^{[1
,7
]}

机构：

[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, Sao Paulo, Brazil

[2] Univ Complutense Madrid, Fac Biol, Dept Genet Physiol & Microbiol, Madrid, Spain

[3] Natl Univ Trujillo, La Libertad, Peru

[4] Natl Inst Hlth, Bacterial Vector Borne Dis Lab, Lima, Peru

[5] Rockefeller Univ, Vertebrate Genome Lab, New York, NY USA

[6] Tri Inst Program Computat Biol & Med, New York, NY USA

[7] Univ Sao Paulo, Sch Vet Med, Dept Pathol, Ave Prof Orlando M Paiva 87, BR-05508270 Sao Paulo, Brazil

来源：

VETERINARY QUARTERLY | 2024年 / 44卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Mardivirus gallidalpha2; meq oncoprotein; selective pressure; phylodynamics; phylogeography; POLYMERASE-CHAIN-REACTION; PATHOGENICITY; ASSOCIATION; SEROTYPE-1; GENE;

D O I：

10.1080/01652176.2024.2318198

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Marek's disease virus (MDV) has become an increasingly virulent pathogen in the poultry industry despite vaccination efforts to control it. Brazil has experienced a significant rise of Marek's disease (MD) outbreaks in recent years. Our study aimed to analyze the complete meq gene sequences to understand the molecular epidemiological basis of MD outbreaks in Brazilian vaccinated layer farms. We detected a high incidence rate of visceral MD (67.74%) and multiple circulating MDV strains. The most prevalent and geographically widespread genotype presented several clinical and molecular characteristics of a highly virulent strain and evolving under positive selective pressure. Phylogenetic and phylogeographic analysis revealed a closer relationship with strains from the USA and Japan. This study sheds light on the circulation of MDV strains capable of infecting vaccinated birds. We emphasize the urgency of adopting preventive measures to manage MDV outbreaks threatening the poultry farming industry.

引用

页码：1 / 13

页数：13

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