The science of micronutrients in clinical practice- Report on the ESPEN symposium

被引：3

作者：

Berger, Mette M. ^{[1
]}

Amrein, Karin ^{[2
]}

Barazzoni, Rocco ^{[3
]}

Bindels, Laure ^{[4
]}

Breton, Irene ^{[5
]}

Calder, Philip C. ^{[6
,7
]}

Cappa, Stefano ^{[8
]}

Cuerda, Cristina ^{[9
]}

D'Amelio, Patrizia ^{[10
]}

de Man, Angelique ^{[11
]}

Delzenne, Nathalie M. ^{[12
]}

Forbes, Alastair ^{[13
]}

Genton, Laurence ^{[14
]}

Gombart, Adrian F. ^{[15
]}

Joly, Francisca ^{[16
]}

Laviano, Alessandro ^{[17
]}

Matthys, Christophe ^{[18
]}

Phyo, Pyi Pyi ^{[19
]}

Ravasco, Paula ^{[20
]}

Serlie, Mireille J. ^{[21
]}

Shenkin, Alan ^{[22
]}

Stoffel, Nicole U. ^{[23
,24
]}

Talwar, Dinesh ^{[25
]}

Zanten, Arthur R. H. van ^{[26
,27
]}

机构：

[1] Univ Lausanne, Fac Biol & Med, CH-1005 Lausanne, Switzerland

[2] Med Univ Graz, Dept Internal Med, Div Endocrinol & Diabetol, A-8036 Graz, Austria

[3] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy

[4] Catholic Univ Louvain, Fac Pharm & Biomed Sci, Louvain Drug Res Inst, B-1200 Brussels, Belgium

[5] Hosp Gen Univ Gregorio Maranon, Nutr Unit, Madrid, Spain

[6] Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton SO16 6YD, England

[7] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton SO16 6YD, England

[8] Univ Sch Adv Studies IUSS Pavia, IUSS Cognit Neurosci ICoN Ctr, I-27100 Pavia, Italy

[9] Univ Complutense Madrid, Dept Med, Nutr Unit, Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[10] CHU Vaudois, Serv Geriatrie & Readaptat Geriatr, Dept Med, Lausanne, Switzerland

[11] Amsterdam Infect & Immun Inst, Res VUMC Intens Care, Dept Intens Care Med, Amsterdam Cardiovasc Sci, Amsterdam, Netherlands

[12] Catholic Univ Louvain, Metab & Nutr Res Grp, Louvain Drug Res Inst, Brussels, Belgium

[13] Univ Tartu, Inst Clin Med, Tartu, Estonia

[14] Geneva Univ Hosp, Clin Nutr Unit, Dept Endocrinol, Geneva, Switzerland

[15] Oregon State Univ, Linus Pauling Inst, Dept Biochem & Biophys, Corvallis, OR 97331 USA

[16] Univ Paris VII, Hosp Beaujon, AP HP, Clichy, France

[17] Univ Roma La Sapienza, Dept Translat & Precis Med, Rome, Italy

[18] Katholieke Univ Leuven, Human Nutr, Leuven, Belgium

[19] WHO Reg Off Europe, WHO European Off Prevent & Control Noncommunicabl, Copenhagen, Denmark

[20] Univ Lisbon, Catolica Med Sch, Curricular Units Diabet Obes & Lifestyle Digest &, Lisbon, Portugal

[21] Univ Amsterdam, Med Ctr, Dept Endocrinol & Metab, Amsterdam, Netherlands

[22] Univ Liverpool, Inst Aging & Chron Dis, Liverpool, Merseyside, England

[23] ETH, Lab Human Nutr, Dept Hlth Sci & Technol, Zurich, Switzerland

[24] Univ Oxford, John Radcliffe Hosp, MRC Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford, England

[25] Glasgow Royal Infirm, Dept Biochem, Glasgow, Scotland

[26] Gelderse Vallei Hosp, Ede, Netherlands

[27] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands

来源：

CLINICAL NUTRITION | 2024年 / 43卷 / 01期

关键词：

Trace element; Vitamin; Deficiency; Epidemiology; Immunity; Inflammation; CRITICALLY-ILL PATIENTS; VITAMIN-D DEFICIENCY; PRODUCT SHORTAGE; TRACE-ELEMENTS; SELENIUM DEFICIENCY; REFEEDING SYNDROME; NUTRITION; SUPPLEMENTATION; DISEASE; METAANALYSIS;

D O I：

10.1016/j.clnu.2023.12.006

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background & aims: The European Society for Clinical Nutrition and Metabolism published its first clinical guidelines for use of micronutrients (MNs) in 2022. A two-day web symposium was organized in November 2022 discussing how to apply the guidelines in clinical practice. The present paper reports the main findings of this symposium.Methods: Current evidence was discussed, the first day being devoted to clarifying the biology underlying the guidelines, especially regarding the definition of deficiency, the impact of inflammation, and the roles in antioxidant defences and immunity. The second day focused on clinical situations with high prevalence of MN depletion and deficiency.Results: The importance of the determination of MN status in patients at risk and diagnosis of deficiencies is still insufficiently perceived, considering the essential role of MNs in immune and antioxidant defences. Epidemiological data show that deficiencies of several MNs (iron, iodine, vitamin D) are a global problem that affects human health and well-being including immune responses such as to vaccination. Clinical conditions frequently associated with MN deficiencies were discussed including cancer, obesity with impact of bariatric surgery, diseases of the gastrointestinal tract, critical illness, and aging. In all these conditions, MN deficiency is associated with worsening of outcomes. The recurrent problem of shortage of MN products, but also lack of individual MN-products is a worldwide problem.Conclusion: Despite important progress in epidemiology and clinical nutrition, numerous gaps in practice persist. MN depletion and deficiency are frequently insufficiently searched for in clinical conditions, leading to inadequate treatment. The symposium concluded that more research and continued education are required to improve patient outcome.(c) 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页码：268 / 283

页数：16

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