Perianal Cutaneous Spindle Cell Squamous Cell Carcinoma With Myxoid Stroma: Case Report and Literature Review

被引：2

作者：

Zhurauliou, Aliaksandr ^{[1
]}

Vasyukova, Olesya ^{[2
]}

机构：

[1] LTD UNIM, Pathol Lab, Skolkovo, Russia

[2] Human Morphol Fed State Budgetary Sci Inst FSBSI, Avtsyn Res Inst, Petrovsky Natl Res Ctr Surg, Clin Morphol Lab, Moscow, Russia

来源：

AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2023年 / 45卷 / 09期

关键词：

squamous cell carcinoma; spindle cell; pathology; immunohistochemistry; VULVA;

D O I：

10.1097/DAD.0000000000002504

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Spindle cell squamous cell carcinoma with myxoid stroma is a rare variant of squamous cell carcinoma with sarcomatoid morphology. We report a case of a 75-year-old woman with an ulcerated polypoid cutaneous mass in the perianal area. The patient had a history of clear cell renal cell carcinoma. Microscopy revealed an invasive myxoid spindle cell carcinoma without the classic squamous cell carcinoma component. The immunohistochemical study demonstrated diffuse positive reactions for p63, AE1/3, and CK5/6. The tumor cells were negative for desmin, smooth muscle actin, S100, and CD34. Fluorescent in situ hybridization was negative for EWSR1 gene rearrangement. Follow-up was remarkable for recurrence of tumor in 2 months after complete resection with negative surgical margin. This is the first case report of perianal spindle cell squamous cell carcinoma with myxoid stroma with a literature review of previous case reports from different locations.

引用

页码：650 / 653

页数：4

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