Perianal Cutaneous Spindle Cell Squamous Cell Carcinoma With Myxoid Stroma: Case Report and Literature Review

被引：3
作者：
Zhurauliou, Aliaksandr [1 ]
Vasyukova, Olesya [2 ]
机构：
[1] LTD UNIM, Pathol Lab, Skolkovo, Russia
[2] Human Morphol Fed State Budgetary Sci Inst FSBSI, Avtsyn Res Inst, Petrovsky Natl Res Ctr Surg, Clin Morphol Lab, Moscow, Russia
来源：
AMERICAN JOURNAL OF DERMATOPATHOLOGY | 2023年 / 45卷 / 09期
关键词：
squamous cell carcinoma; spindle cell; pathology; immunohistochemistry; VULVA;
D O I：
10.1097/DAD.0000000000002504
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Spindle cell squamous cell carcinoma with myxoid stroma is a rare variant of squamous cell carcinoma with sarcomatoid morphology. We report a case of a 75-year-old woman with an ulcerated polypoid cutaneous mass in the perianal area. The patient had a history of clear cell renal cell carcinoma. Microscopy revealed an invasive myxoid spindle cell carcinoma without the classic squamous cell carcinoma component. The immunohistochemical study demonstrated diffuse positive reactions for p63, AE1/3, and CK5/6. The tumor cells were negative for desmin, smooth muscle actin, S100, and CD34. Fluorescent in situ hybridization was negative for EWSR1 gene rearrangement. Follow-up was remarkable for recurrence of tumor in 2 months after complete resection with negative surgical margin. This is the first case report of perianal spindle cell squamous cell carcinoma with myxoid stroma with a literature review of previous case reports from different locations.
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收藏
页码：650 / 653
页数：4
相关论文
共 21 条
[1]  
Bachurska Svitlana Y, 2017, Folia Med (Plovdiv), V59, P232, DOI 10.1515/folmed-2017-0002
[2]   Primary Cutaneous Myxoid Spindle Cell Squamous Cell Carcinoma of the Scalp: A Case Report [J].
Bedir, Recep ;
Suntur, Mehpare ;
Semerci, Orhan .
TURKISH JOURNAL OF PATHOLOGY, 2021, 37 (01) :67-70
[3]   Cutaneous Squamous Cell Carcinoma With Mucinous Metaplasia on the Sole Associated With High-Risk Human Papillomavirus Type 18 [J].
Caputo, Valentina ;
Colombi, Roberto ;
Ribotta, Marisa ;
Rongioletti, Franco .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2011, 33 (03) :317-322
[4]   Rare Mimic of a Myxofibrosarcoma: Cutaneous Myxoid Spindle Cell Squamous Cell Carcinoma as a Complication of Chronic Osteomyelitis [J].
Chen, Michelle K. Y. ;
Henderson, Christopher J. A. ;
Rutland, Tristan .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2022, 44 (07) :526-528
[5]   Squamous cell carcinoma with sarcomatoid features of the vulva: A case report and review of literature [J].
Choi, Dong-Seok ;
Lee, Jeong-Won ;
Lee, Sun-Joo ;
Choi, Chel Hun ;
Kim, Tae-Joong ;
Lee, Je-Ho ;
Bae, Duk-Soo ;
Ahn, Geunghwan ;
Kim, Byoung-Gie .
GYNECOLOGIC ONCOLOGY, 2006, 103 (01) :363-367
[6]   Sarcomatoid squamous cell carcinoma of the vulva [J].
Cooper, WA ;
Valmadre, S ;
Russell, P .
PATHOLOGY, 2002, 34 (02) :197-199
[7]   New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer [J].
Dongre, Anushka ;
Weinberg, Robert A. .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2019, 20 (02) :69-84
[8]  
Elder D. E., 2018, WHO classification of skin tumours: 11. WHO classification of skin tumours, V4th
[9]   EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases [J].
Flucke, Uta ;
Palmedo, Gabriele ;
Blankenhorn, Nina ;
Slootweg, Pieter J. ;
Kutzner, Heinz ;
Mentzel, Thomas .
MODERN PATHOLOGY, 2011, 24 (11) :1444-1450
[10]   SQUAMOUS-CELL CARCINOMA WITH PROMINENT MYXOID STROMA [J].
FOSCHINI, MP ;
FULCHERI, E ;
BARACCHINI, P ;
CECCARELLI, C ;
BETTS, CM ;
EUSEBI, V .
HUMAN PATHOLOGY, 1990, 21 (08) :859-865
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