The effect of Nigella sativa extracts against Porphyromonas gingivalis isolated from periodontitis patients

OBJECTIVE: Periodontitis is an inflammatory condition that results in pocket formation, gingival recession, and tooth loss by gradually destroying the periodontium. An al-ternate therapeutic approach that can address these problems is required due to the prohibitive cost of periodontal therapy, unfavorable antibiotic side effects, the advent of novel bacterial strains, and the resistance of those strains. The primary goal of our study was to assess Nigella sativa's (N. sativa) antibacterial effective-ness against Porphyromonas gingivalis (P. gingivalis) utilizing seed extract.PATIENTS AND METHODS: Six individuals with periodontitis, both male and female, be-tween the ages of 30 and 50, were enrolled in the study. Each patient's medical and dental histories were documented. Then, anaerobic procedures were conducted in the microbiology lab to find P. gingivalis development. The specimens were all then cultured.RESULTS: At 12.5 mg/ml concentration, P. gingivalis did not show any zone of inhibition (ZOI). However, N. sativa, at a concentration of 25 mg/ ml, demonstrated a ZOI of 6.2 mm against P. gingivalis. Similarly, at 50 mg/ml, it showed a ZOI of 8.4 mm. Tetracycline as a positive control demonstrated a ZOI of 14.1 mm against P. gingivalis. Although N. sativa samples had somewhat less antibacterial activity than tetracycline samples, it was discovered that N. sativa had notice-able antibacterial activity against P. gingivalis.CONCLUSIONS: This study's findings suggest that N. sativa can be utilized against periodontitis as an adjunct to scaling since it has high antibacterial action against P. gingivalis.