Chemical composition, antibacterial and cytotoxic activities of essential oil obtained from aerial parts of Aeschynomene denticulata Rudd

被引：0

作者：

de Sa, Rodrigo Elisio ^{[1
]}

Araujo, Gisele Santos ^{[1
]}

Santos Machado, Fabricio dos ^{[1
]}

Araujo, Dakson Douglas ^{[1
]}

da Silva, Rai Emanuel ^{[2
]}

Santiago, Rodrigo Ferreira ^{[3
]}

Gomes de Almeida, Lorena Tuane ^{[3
]}

Barreto Marinho Filho, Jose Delano ^{[1
]}

de Araujo, Alyne Rodrigues ^{[2
]}

Chaves, Mariana Helena ^{[3
]}

Araujo, Ana Jersia ^{[1
]}

机构：

[1] Univ Fed Delta Parnaiba, Lab Cultura Celulas Delta LCCDelta, UFDPar, BR-64202020 Parnaiba, PI, Brazil

[2] Univ Fed Delta Parnaiba, Nucleo Pesquisa Biodiversidade & Biotecnol, Biotec, UFDPar, BR-64202020 Parnaiba, PI, Brazil

[3] Univ Fed Piaui, Dept Quim, Lab Prod Nat, Teresina, PI, Brazil

来源：

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY | 2023年 / 54卷

基金：

巴西圣保罗研究基金会;

关键词：

Aeschynomene denticulata; Antibacterial; Cytotoxicity; Essential oils; Volatile composition; ANTIMICROBIAL ACTIVITY; CONSTITUENTS; PLANTS; RICE;

D O I：

10.1016/j.bcab.2023.102908

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Essential oils obtained from plants showed pharmacological potential thus the pharmaceutical industry demonstrates interest in exploring this field. In the present study chemical composition, antibacterial and cytotoxic potential of essential oil obtained from Aeschynomene denticulata Rudd (AD-EO) aerial parts were evaluated. The major composition of essential oil was determined by gas chromatography and mass spectrometry. The main compounds were alpha-pinene (30.6%), beta-pinene (20.8%), germacrene D (13.1%) and sabinene (9.3%). Our results showed that Staphylococcus epidermidis ATCC 12228 and Staphylococcus aureus ATCC 29213 were the most sensitive to AD-EO. Furthermore, results provided by atomic force microscopy images showed that AD-EO treatment altered S. aureus morphology. Cytotoxic activity was observed in all cell lines evaluated, with human colorectal tumor line (HCT-116) as the most susceptible. Morphological changes specially cell death characteristics were also observed in HCT-116 cells. In relation to toxicity, AD-EO did not show haemolytic activity against human erythrocytes. Our results demonstrate antibacterial and antiproliferative potential of AD-EO, its therapeutic potential and application of this plant, which no commercial value was previously mensuared by industry. This study presents the first biological activity of AD-EO.

引用

页数：11

共 51 条

[1] Interference and Economic Weed Threshold (Ewt) of Barnyardgrass on Rice as a Function of Crop Plant Arrangement [J].

Agostinetto, D. ;

Galon, L. ;

Silva, J. M. B., V ;

Tironi, S. P. ;

Andres, A. .

PLANTA DANINHA, 2010, 28 :993-1003

[2] In vitro and in vivo inhibition of HCT116 cells by essential oils from bark and leaves of Virola surinamensis (Rol. ex Rottb.) Warb. (Myristicaceae) [J].

Anunciacao, Talita A. ;

Costa, Rafaela G. A. ;

de Lima, Emilly J. S. P. ;

Silva, Valdenizia R. ;

Santos, Luciano de S. ;

Soares, Milena B. P. ;

Dias, Rosane B. ;

Gurgel Rocha, Clarissa A. ;

Costa, Emmanoel, V ;

da Silva, Felipe M. A. ;

Koolen, Hector H. F. ;

Bezerra, Daniel P. .

JOURNAL OF ETHNOPHARMACOLOGY, 2020, 262

[3] Biological effects of essential oils - A review [J].

Bakkali, F. ;

Averbeck, S. ;

Averbeck, D. ;

Waomar, M. .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (02) :446-475

[4]

Bayala B, 2014, AM J CANCER RES, V4, P591

[5]

Carson C F., 2010, Lipids and Essential Oils as Antimicrobial Agents, P203, DOI DOI 10.1002/9780470976623.CH9

[6] Melaleuca alternifolia (tea tree) oil:: a review of antimicrobial and other medicinal properties [J].

Carson, CF ;

Hammer, KA ;

Riley, TV .

CLINICAL MICROBIOLOGY REVIEWS, 2006, 19 (01) :50-+

[7] Secundiflorol G isolated from Aeschynomene fascicularis, a Mayan medicinal plant, induces apoptosis in cervical cancer cells [J].

Castillo-Bautista, Cristina M. ;

Torres-Tapia, Luis W. ;

Lagunas-Martinez, Alfredo ;

Contreras-Ochoa, Carla O. ;

Peraza-Sanchez, Sergio R. ;

Moo-Puc, Rosa .

NATURAL PRODUCT RESEARCH, 2021, 35 (05) :826-828

[8] Essential Oil from Cryptomeria japonica Induces Apoptosis in Human Oral Epidermoid Carcinoma Cells via Mitochondrial Stress and Activation of Caspases [J].

Cha, Jeong-Dan ;

Kim, Ji-Young .

MOLECULES, 2012, 17 (04) :3890-3901

[9]

CLSI-Clinical Laboratory Standards Institute, 2016, Approved Standard M02-A10

[10] The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffii oleo-resin [J].

Costa-Lotufo, LV ;

Cunha, GMA ;

Farias, PAM ;

Viana, GSB ;

Cunha, KMA ;

Pessoa, C ;

Moraes, MO ;

Silveira, ER ;

Gramosa, NV ;

Rao, VSN .

TOXICON, 2002, 40 (08) :1231-1234

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