Antibody Responses to Influenza Vaccination are Diminished in Patients With Inflammatory Bowel Disease on Infliximab or Tofacitinib

被引：1

作者：

Liu, Zhigang ^{[1
]}

Alexander, James L. ^{[1
,2
,3
]}

Eng, Kai Yee ^{[1
]}

Ibraheim, Hajir ^{[1
,2
]}

Anandabaskaran, Sulak ^{[1
,3
]}

Saifuddin, Aamir ^{[1
,3
]}

Constable, Laura ^{[1
]}

Seoane, Rocio Castro ^{[1
]}

Bewshea, Claire ^{[4
]}

Nice, Rachel ^{[4
,5
]}

D'Mello, Andrea ^{[6
]}

Jones, Gareth R. ^{[7
,8
]}

Balarajah, Sharmili ^{[1
,2
]}

Fiorentino, Francesca ^{[9
,10
]}

Sebastian, Shaji ^{[11
,12
]}

Irving, Peter M. ^{[13
,14
]}

Hicks, Lucy C. ^{[1
,2
]}

Williams, Horace R. T. ^{[1
,2
]}

Kent, Alexandra J. ^{[15
]}

Linger, Rachel ^{[16
]}

Parkes, Miles ^{[16
,17
]}

Kok, Klaartje ^{[18
]}

Patel, Kamal, V ^{[19
]}

Teare, Julian P. ^{[1
,2
,4
]}

Altmann, Daniel M. ^{[20
]}

Boyton, Rosemary J. ^{[21
,22
]}

Hart, Ailsa L. ^{[3
]}

Lees, Charlie W.

Goodhand, James R.

Kennedy, Nicholas A.

Pollock, Katrina M. ^{[21
,24
,25
]}

Ahmad, Tariq ^{[4
,23
]}

Powell, Nick ^{[1
,2
,26
]}

机构：

[1] Imperial Coll London, Dept Metab Digest & Reprod, London, England

[2] Imperial Coll Healthcare NHS Trust, Dept Gastroenterol, London, England

[3] St Marks Hosp & Acad Inst, Dept Gastroenterol, Gastroenterol, London, England

[4] Univ Exeter, Exeter Inflammatory Bowel Dis & Pharmacogenet Res, Exeter, England

[5] Royal Devon Univ Healthcare NHS Fdn Trust, Dept Clin Chem, Exeter Clin Lab Int, Exeter, England

[6] Imperial Coll Healthcare NHS Trust, Div Med & Integrated Care, London, England

[7] Western Gen Hosp, NHS Lothian, Dept Gastroenterol, Edinburgh, Scotland

[8] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, Edinburgh, Scotland

[9] Imperial Coll London, Dept Surg & Canc, London, England

[10] Kings Coll London, Nightingale Saunders Clin Trials & Epidemiol Unit, Kings Clin Trials Unit, London, England

[11] Hull Univ Teaching Hosp NHS Trust, Dept Gastroenterol, Kingston Upon Hull, England

[12] Univ Hull, Hull York Med Sch, Kingston Upon Hull, England

[13] Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London, England

[14] Kings Coll London, Sch Immunol & Microbial Sci, London, England

[15] Kings Coll Hosp London, Dept Gastroenterol, London, England

[16] Univ Cambridge, NIHR Bioresource, Cambridge, England

[17] Cambridge Univ Hosp NHS Trust, Dept Gastroenterol, Cambridge, England

[18] Barts Hlth NHS Trust, Dept Gastroenterol, London, England

[19] St Georges Hosp NHS Trust, Dept Gastroenterol, London, England

[20] Imperial Coll London, Dept Immunol & Inflammat, London, England

[21] Imperial Coll London, Dept Infect Dis, London, England

[22] Guys & St Thomas NHS Fdn Trust, Royal Brompton & Harefield Hosp, Lung Div, London, England

[23] Royal Devon Univ Healthcare NHS Fdn Trust, Dept Gastroenterol, Exeter, England

[24] NIHR Imperial Clin Res Facil, London, England

[25] NIHR Imperial Biomed Res Ctr, London, England

[26] Imperial Coll London, Fac Med, Dept Metab Digest & Reprod, Div Digest Dis, Du Cane Rd, London W12 0NN, England

来源：

JOURNAL OF CROHNS & COLITIS | 2024年 / 18卷 / 04期

基金：

英国惠康基金; 欧盟地平线“2020”; “创新英国”项目; 英国科研创新办公室;

关键词：

JAK-inhibitor; anti-TNF; humoral immunity; immunisation; REPORTED OUTCOME MEASURES; IMMUNE-RESPONSE; TNF-ALPHA; T-CELLS; MULTICENTER; VARIANTS; IBD;

D O I：

10.1093/ecco-jcc/jjad182

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and Aims: We sought to determine whether six commonly used immunosuppressive regimens were associated with lower antibody responses after seasonal influenza vaccination in patients with inflammatory bowel disease [IBD].Methods: We conducted a prospective study including 213 IBD patients and 53 healthy controls: 165 who had received seasonal influenza vaccine and 101 who had not. IBD medications included infliximab, thiopurines, infliximab and thiopurine combination therapy, ustekinumab, vedolizumab, or tofacitinib. The primary outcome was antibody responses against influenza/A H3N2 and A/H1N1, compared to controls, adjusting for age, prior vaccination, and interval between vaccination and sampling.Results: Lower antibody responses against influenza A/H3N2 were observed in patients on infliximab (geometric mean ratio 0.35 [95% confidence interval 0.20-0.60], p = 0.0002), combination of infliximab and thiopurine therapy (0.46 [0.27-0.79], p = 0.0050), and tofacitinib (0.28 [0.14-0.57], p = 0.0005) compared to controls. Lower antibody responses against A/H1N1 were observed in patients on infliximab (0.29 [0.15-0.56], p = 0.0003), combination of infliximab and thiopurine therapy (0.34 [0.17-0.66], p = 0.0016), thiopurine monotherapy (0.46 [0.24-0.87], p = 0.017), and tofacitinib (0.23 [0.10-0.56], p = 0.0013). Ustekinumab and vedolizumab were not associated with reduced antibody responses against A/H3N2 or A/H1N1. Vaccination in the previous year was associated with higher antibody responses to A/H3N2. Vaccine-induced anti-SARS-CoV-2 antibody concentration weakly correlated with antibodies against H3N2 [r = 0.27; p = 0.0004] and H1N1 [r = 0.33; p < 0.0001].Conclusions: Vaccination in both the 2020-2021 and 2021-2022 seasons was associated with significantly higher antibody responses to influenza/A than no vaccination or vaccination in 2021-2022 alone. Infliximab and tofacitinib are associated with lower binding antibody responses to influenza/A, similar to COVID-19 vaccine-induced antibody responses.

引用

页码：560 / 569

页数：10

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