A comparative study on oxidative stress indices among cattle and buffalo with foreign body syndrome

This study aimed to compare the oxidative stress indicesamong cattle and buffalowith foreign body syndrome (FBS) in order to clarify this syndrom's pathogenesis and explain the clinical differences between both species.The study included60 animals. They were divided into acontrol group (10 healthy cows and 10 healthybuffalo-cows). The diseasedanimals were divided based on the clinical signs and duration of illness as well as radiographic and ultrasonographic findings into3 groups;acute local TRP (5 buffalo-cows),chroniclocal traumatic reticuloperitonitis(TRP) (13 cows and 12 buffalo-cows), and traumatic pericarditis(TP) (5cows and 5 buffalo-cows). Blood samples were obtained for hematological and biochemical analysis. In all diseased animals, the malondialdehyde (MDA) level, Glutathione peroxidase(GSH-PX)and superoxide dismutase (SOD) activities increased significantly except in buffalo with chronic local TRP,GSH-PX activity decreased significantly.The reduced glutathione (GSH) and catalase activitiesdecreasedalso significantly in all diseased groups. The level of TAC was only increased significantly in acute local TRP in buffalo-cows. Statisticaly, there was a species difference in MDA level, in which cattle surpass buffalo in production of lipidperoxides which indicate more oxidative damage and more inflammation and systemic reactions. Whereas, buffalo with chronic local TRP showed an exhausted antioxidant defense system because of lower GSH-PX activity than in cattle that leading to more chronic changes and fibrosis.Finaly, it can be concluded that there is a species difference between cattle and buffalo in lipid peroxidation and their antioxidant defence mechanism response to oxidative stress in FBS and its sequalae which could affect on the clinical signs and the progress of the disease in each species. Future researches should focus on establishment of reference oxidative stress panel for each speciesin order to determine approparate oxidative stress biomarkers andantioxidant therapy