Pulmonary embolism in COVID-19 pneumonia patients admitted to temporary hospital - The follow-up study

被引:1
作者
Lewczuk, Tomasz [1 ]
Kazimierczyk, Remigiusz [1 ]
Sobkowicz, Bozena [1 ]
Lisowska, Anna [1 ,2 ]
机构
[1] Med Univ Bialystok, Dept Cardiol, Bialystok, Poland
[2] Med Univ Bialystok, Dept Cardiol, Marii Sklodowskiej Curie 24a, PL-15276 Bialystok, Poland
来源
ADVANCES IN MEDICAL SCIENCES | 2023年 / 68卷 / 02期
关键词
Pulmonary embolism; COVID-19; Prognosis;
D O I
10.1016/j.advms.2023.08.002
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Purpose: Coronavirus disease 2019 (COVID-19) is linked with major coagulation disorders, especially higher risk of developing pulmonary embolism (PE). Our study summarizes COVID-19 patients' management with concomitant PE during the first weeks of pandemic and underlines the importance of D-dimer concentration assessment at admission in terms of prognosis. Material and methods: Study group consisted of 107 outpatients (mean age 68.91 +/- 12.83 years) admitted to the Temporary COVID-19 Hospital in Bialystok, Poland with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and suspicion of PE based on elevated D-dimer concentration (>500 mu g/l) and/or low saturation rate (<90%). The clinical follow-up lasted 6 months. Death or re-hospitalization were used as composite clinical endpoint (CEP). Results: Cumulative incidence of PE was 62.3% (73/107 patients). Most of the patients were in the intermediate PE risk group according to the pulmonary embolism severity index (PESI) score. The mean total computed tomography (CT) lung involvement of COVID-19 findings was 48.42 +/- 27.71%. Neither D-dimers nor NT-proBNP concentrations correlated significantly with the percentage of lung abnormalities in CT. Patients with baseline Ddimer concentration higher than 1429 mu g/l had worse prognosis in 6-months observation, log-rank test, p 1/4 0.009. Conclusions: Ongoing SARS-CoV-2 infection along with massive involvement of lung tissue and concomitant thrombi in pulmonary arteries are challenging for physicians. It seems that simple D-dimer concentration assessment at admission may be a helpful tool not only to predict PE but also to estimate the long-term prognosis.
引用
收藏
页码:270 / 275
页数:6
相关论文
共 50 条
[41]   Characteristics of Acute Pulmonary Embolism in Patients With COVID-19 Associated Pneumonia From the City of Wuhan [J].
Chen, Jianpu ;
Wang, Xiang ;
Zhang, Shutong ;
Lin, Bin ;
Wu, Xiaoqing ;
Wang, Yanfang ;
Wang, Xiaoqi ;
Yang, Ming ;
Sun, Jianqing ;
Xie, Yuanliang .
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2020, 26
[42]   Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review [J].
Yasser Sakr ;
Manuela Giovini ;
Marc Leone ;
Giacinto Pizzilli ;
Andreas Kortgen ;
Michael Bauer ;
Tommaso Tonetti ;
Gary Duclos ;
Laurent Zieleskiewicz ;
Samuel Buschbeck ;
V. Marco Ranieri ;
Elio Antonucci .
Annals of Intensive Care, 10
[43]   D-Dimer Assessment to Predict Pulmonary Embolism in ICU Patients with COVID-19 Pneumonia [J].
Louwsma, Jelger ;
Langeveld, Bas ;
Luyendijk, Jacqueline M. ;
van den Oever, Huub L. A. .
COVID, 2023, 3 (09) :1380-1388
[44]   Thoracic ultrasonographic and clinical findings at 12-month follow-up of patients admitted with COVID-19 [J].
Falster, Casper ;
Juul, Amanda ;
Jacobsen, Niels ;
Skov, Inge Raadal ;
Rasmussen, Line Dahlerup ;
Madsen, Lone Wulff ;
Johansen, Isik Somuncu ;
Harders, Stefan Markus Walbom Harders ;
Davidsen, Jesper Romhild ;
Laursen, Christian B. .
EUROPEAN CLINICAL RESPIRATORY JOURNAL, 2023, 10 (01)
[45]   Pulmonary embolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: a narrative review [J].
Sakr, Yasser ;
Giovini, Manuela ;
Leone, Marc ;
Pizzilli, Giacinto ;
Kortgen, Andreas ;
Bauer, Michael ;
Tonetti, Tommaso ;
Duclos, Gary ;
Zieleskiewicz, Laurent ;
Buschbeck, Samuel ;
Ranieri, V. Marco ;
Antonucci, Elio .
ANNALS OF INTENSIVE CARE, 2020, 10 (01)
[46]   Pulmonary fibrotic-like changes on follow-up chest CT exam in patients recovering from COVID-19 pneumonia [J].
Vural, Ahmet ;
Kahraman, Ahmet Nedim .
TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX, 2021, 69 (04) :492-498
[47]   Diagnosis of COVID-19 in Patients with Acute Pulmonary Embolism [J].
Koc, Ibrahim ;
Yildiz, Ozlem ;
Babalik, Mesiha ;
Isigibol, Rahime Ozgur ;
Ozmen, Sevda Unalli ;
Zeytinoglu, Duygu ;
Savas, Nazan Nalci ;
Yapici, Ilhami ;
Celikten, Halil ;
Demirsoy, Sedat ;
Deniz, Olgun .
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2023, 260 (02) :127-133
[48]   Complications in COVID-19 patients: Characteristics of pulmonary embolism [J].
Cau, Riccardo ;
Pacielli, Alberto ;
Fatemeh, Homayounieh ;
Vaudano, Paolo ;
Arru, Chiara ;
Crivelli, Paola ;
Stranieri, Giuseppe ;
Suri, Jasjit S. ;
Mannelli, Lorenzo ;
Conti, Maurizio ;
Mahammedi, Abdelkader ;
Kalra, Mannudeep ;
Saba, Luca .
CLINICAL IMAGING, 2021, 77 :244-249
[49]   Prospective six months follow-up analysis of the serological response to SARS-CoV-2 in a cohort of patients admitted for COVID-19 pneumonia [J].
Leal Garcia, Miguel Angel ;
Costa Sola, Roser ;
Barreiro Lopez, Bienvenido ;
Grau Gomez, Gemma ;
Jaen Manzanera, Angels ;
Padilla Esteba, Emma ;
Sanz Santos, Jose ;
Esteban Tejero, Lluis ;
Lozano Bailen, Loures ;
Lapuente Torrents, Ana Maria ;
Martinez Palau, Mireia ;
Garcia Cabo, Bruno ;
Pribic, Teodora ;
Martinez Del Pozo, Ester ;
Martinez Lacasa, Xavier .
EUROPEAN RESPIRATORY JOURNAL, 2021, 58
[50]   Pulmonary embolism and SARS-CoV-2: analysis of the characteristics of patients admitted to a center in northern Italy for pulmonary embolism associated with COVID-19 [J].
Zanchi, Simone ;
La Greca, Carmelo ;
Forgione, Chiara ;
Bettari, Luca ;
Cortinovis, Sarah ;
Pero, Gaetano ;
Pecora, Domenico ;
Botti, Paolo ;
Bna, Claudio ;
Cuccia, Claudio .
GIORNALE ITALIANO DI CARDIOLOGIA, 2021, 22 (09) :704-711