Is the Anal Component of the Anogenital HPV-Related Disease Overlooked During the Surveillance of Patients Treated for Cervical Intraepithelial Neoplasia?

被引：0

作者：

Ozgen, Utku ^{[1
]}

Guler, Tolga ^{[2
]}

Kilic, Derya ^{[2
]}

Gokakin, Ali ^{[3
]}

Aykota, Muhammed ^{[4
]}

Kaleli, Ilknur ^{[5
]}

Karakaya, Yeliz Arman ^{[6
]}

Sungurtekin, Ugur ^{[4
]}

机构：

[1] Pamukkale Univ, Surg, Denizli, Turkiye

[2] Pamukkale Univ, Obstet & Gynecol, Denizli, Turkiye

[3] Lokman Hekim Etlik Private Hosp, Gen Surg, Ankara, Turkiye

[4] Pamukkale Univ, Gen Surg, Denizli, Turkiye

[5] Pamukkale Univ, Microbiol, Denizli, Turkiye

[6] Pamukkale Univ, Pathol, Denizli, Turkiye

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 09期

关键词：

screening; cervical cancer; cervical intraepithelial neoplasia; anal cancer; human papillomavirus; HUMAN-PAPILLOMAVIRUS INFECTION; WOMEN; CANCER; CYTOLOGY; RISK; MEN; DNA;

D O I：

10.7759/cureus.44731

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To investigate the anal component of the anogenital Human Papillomavirus (HPV) related disease during surveillance of patients treated for cervical intraepithelial neoplasia (CIN).Methods: Patients were analyzed within two groups according to the histopathological examination of the cervical biopsies: Low-Grade Squamous Intraepithelial Lesion (LSIL) and High-Grade Squamous Intraepithelial Lesion (HSIL) groups. Anal specimens were also collected in the first-year follow-up visit.Results: All patients had cervical high-risk HPV (HR HPV) infection at admission. At the first-year follow-up, positive HR HPVs were found in 47% of cervical samples. Despite this clearance, the anal HPV infection rate after the first year was 42.5% and 39.6% in LSIL and HSIL groups. Amongst the HSIL group, anal HR HPV positivity was observed in 29.6% of cases without any cervical HPV infection.Conclusion: A group of women cured of high-grade lesions have ongoing anal HPV infection. It is reasonable to propose that detecting anal HPV could impact the patient's treatment process. Therefore, prospective studies are needed to investigate this group of women's clinical outcomes and define the clearance rate of cervical HPV infection when anal HPV persists.

引用

页数：8

共 17 条

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Braaten Kari P, 2008, Rev Obstet Gynecol, V1, P2

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