Unrevealing the vital role of ncRNAs in Gastric Cancer chemoresistance

被引：5

作者：

Kazemi, Aida ^{[1
]}

Goodarzi, Masomeh ^{[2
]}

Daneshipour, Kosar ^{[3
]}

Sarabadani, Hoda ^{[4
]}

Shahpar, Zahra ^{[5
]}

Hajiagha, Bahareh Salmanian ^{[6
]}

Kheradjoo, Hadis ^{[7
]}

Mohammadzadehsaliani, Saman ^{[8
]}

机构：

[1] Monash Univ, Dept Biomed Sci, Melbourne, Australia

[2] Zabol Univ Med Sci, Dept Biol, Zabol, Iran

[3] Islamic Azad Univ, Dept Biol Sci, North Tehran Branch, Tehran, Iran

[4] Bharati Vidyapeeth Univ, Rajiv Gandhi Inst Informat Technol & Biotechnol, Pune, India

[5] Istanbul Univ, Tech Dept, Istanbul, Turkiye

[6] Islamic Azad Univ, Fac Basic Sci, Dept Cellular & Mol Biol, East Tehran Branch, Tehran, Iran

[7] Buraimi Hosp, Lab Dept, Buraimi, Oman

[8] Buraimi Hosp, Ophthalmol Dept, Buraimi, Oman

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 250卷

关键词：

Non-coding RNAs; Chemoresistance; Gastric cancer; CISPLATIN RESISTANCE; CELL-PROLIFERATION; CHEMOSENSITIVITY; HETEROGENEITY; INCREASES; PATHOLOGY;

D O I：

10.1016/j.prp.2023.154761

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The high incidence of gastric cancer in many nations and poor overall survival rates has remained a serious global health concern. Chemoresistance in gastric cancer is a significant issue that hinders the efficacy of available treatment options. In gastric cancer, non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs have become effective regulators of chemoresistance. These non-coding RNAs can influence several mechanisms, including drug efflux transporters, drug metabolism, and detoxification, cancer stem cells and the epithelial-mesenchymal transition, autophagy and apoptosis, and the tumor microenvironment. In this article review, we summarize the key roles non-coding RNAs play in the chemoresistance of gastric cancer and consider how they might be used in clinical settings as markers for diagnosis and prognosis, as well as potential targets and treatment plans. We also emphasize the need for additional study and collaborations in this area and highlight the difficulties and opportunities in non-coding RNA research for gastric cancer chemoresistance. This review offers crucial insights into the intricate relationship between non-coding RNAs and chemoresistance in gastric cancer, with implications for precision oncology and personalized medicine.

引用

页数：8

共 74 条

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