Transition-metal-catalyzed C-H bond activation as a sustainable strategy for the synthesis of fluorinated molecules: an overview

被引：13

作者：

Monsigny, Louis ^{[1
]}

Doche, Floriane ^{[1
]}

Besset, Tatiana ^{[1
]}

机构：

[1] Normandie Univ, INSA Rouen, UNIROUEN, COBRA,CNRS,UMR 6014, F-76000 Rouen, France

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 19卷

基金：

欧洲研究理事会;

关键词：

C-H bond activation; emergent fluorinated groups; homogeneous catalysis; organofluorine chemistry; palladium; synthetic method; PD(II)-CATALYZED ORTHO-TRIFLUOROMETHYLATION; TRANSIENT DIRECTING GROUPS; ELECTROPHILIC TRIFLUOROMETHYLTHIOLATION; UNACTIVATED C(SP(3))-H; C(SP(2))-H BONDS; MEDIATED TRIFLUOROMETHYLATION; EFFICIENT SYNTHESIS; FUNCTIONALIZATION; ARYL; ALKOXYLATION;

D O I：

10.3762/bjoc.19.35

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The last decade has witnessed the emergence of innovative synthetic tools for the synthesis of fluorinated molecules. Among these approaches, the transition-metal-catalyzed functionalization of various scaffolds with a panel of fluorinated groups (XRF, X = S, Se, O) offered straightforward access to high value-added compounds. This review will highlight the main advances made in the field with the transition-metal-catalyzed functionalization of C(sp2) and C(sp3) centers with SCF3, SeCF3, or OCH2CF3 groups among others, by C-H bond activation. The scope and limitations of these transformations are discussed in this review.

引用

页码：448 / 473

页数：26

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