Healthcare use and medical cost before and after diagnosis of nontuberculous mycobacterial infection in Korea: the National Health Insurance Service-National Sample Cohort Study

被引:3
作者
Lee, Seung Won [1 ]
Chang, Shihwan [2 ]
Park, Youngmok [2 ]
Kim, Sol [2 ]
Sohn, Hojoon [2 ,3 ]
Kang, Young Ae [1 ,4 ]
机构
[1] Yonsei Univ, Inst Immunol & Immunol Dis, Coll Med, Seoul, South Korea
[2] Yonsei Univ, Severance Hosp, Coll Med, Dept Internal Med, Seoul, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea
[4] Yonsei Univ, Severance Hosp, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea
关键词
cost; nontuberculous mycobacteria infection; respiratory diseases; DISEASE; RISK;
D O I
10.1177/17534666221148660
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background and objective:The global prevalence and incidence of nontuberculous mycobacterial (NTM) infections are increasing; however, population-level data on healthcare use and medical costs for people with NTM infections are limited. Thus, we investigated the rates of healthcare use and medical costs of people with NTM infections in South Korea using the National Health Insurance Service-National Sample Cohort from 2002 to 2015. Methods:In this cohort study, people with and without NTM infection aged 20-89 years were matched 1 to 4 by sex, age, Charlson comorbidity index, and year of diagnosis. The overall and annual average healthcare use and medical costs were calculated. In addition, trends in healthcare use and medical costs for each of the 3 years before and after NTM diagnosis were investigated for people diagnosed with NTM infection. Results:A total of 798 individuals (336 men and 462 women) diagnosed with NTM infection and 3192 controls were included in the study. NTM-infected patients had significantly higher rates of healthcare use and medical costs than those in the control group (p < 0.05). NTM-infected patients showed 1.5 times the medical cost and 4.5 times the respiratory disease cost of the control group. People diagnosed with NTM infection incurred the highest medical costs in the 6 months before diagnosis. Conclusion:NTM infection increases the economic burden on Korean adults. Appropriate diagnostic tests and treatment plans for NTM infections are needed to reduce the burden of the disease caused by such infection.
引用
收藏
页数:11
相关论文
共 30 条
[1]   An Introduction to Propensity Score Methods for Reducing the Effects of Confounding in Observational Studies [J].
Austin, Peter C. .
MULTIVARIATE BEHAVIORAL RESEARCH, 2011, 46 (03) :399-424
[2]   Pulmonary nontuberculous mycobacterial infections: Antibiotic treatment and associated costs [J].
Ballarino, Guillermo J. ;
Olivier, Kenneth N. ;
Claypool, Reginald J. ;
Holland, Steven M. ;
Prevots, D. Rebecca .
RESPIRATORY MEDICINE, 2009, 103 (10) :1448-1455
[3]   Non-tuberculous mycobacterial pulmonary disease [J].
Cowman, Steven ;
van Ingen, Jakko ;
Griffith, David E. ;
Loebinger, Michael R. .
EUROPEAN RESPIRATORY JOURNAL, 2019, 54 (01)
[4]  
Daley CL, 2020, CLIN INFECT DIS, V71, P905, DOI 10.1093/cid/ciaa1125
[5]   Burden of non-tuberculous mycobacterial pulmonary disease in Germany [J].
Diel, Roland ;
Jacob, Josephine ;
Lampenius, Niklas ;
Loebinger, Michael ;
Nienhaus, Albert ;
Rabe, Klaus F. ;
Ringshausen, Felix C. .
EUROPEAN RESPIRATORY JOURNAL, 2017, 49 (04)
[6]   Genomic characterization of Nontuberculous Mycobacteria [J].
Fedrizzi, Tarcisio ;
Meehan, Conor J. ;
Grottola, Antonella ;
Giacobazzi, Elisabetta ;
Serpini, Giulia Fregni ;
Tagliazucchi, Sara ;
Fabio, Anna ;
Bettua, Clotilde ;
Bertorelli, Roberto ;
De Sanctis, Veronica ;
Rumpianesi, Fabio ;
Pecorari, Monica ;
Jousson, Olivier ;
Tortoli, Enrico ;
Segata, Nicola .
SCIENTIFIC REPORTS, 2017, 7
[7]   An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases [J].
Griffith, David E. ;
Aksamit, Timothy ;
Brown-Elliott, Barbara A. ;
Catanzaro, Antonino ;
Daley, Charles ;
Gordin, Fred ;
Holland, Steven M. ;
Horsburgh, Robert ;
Huitt, Gwen ;
Iademarco, Michael F. ;
Iseman, Michael ;
Olivier, Kenneth ;
Ruoss, Stephen ;
von Reyn, C. Fordham ;
Wallace, Richard J., Jr. ;
Winthrop, Kevin .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (04) :367-416
[8]   Population-based Incidence of Pulmonary Nontuberculous Mycobacterial Disease in Oregon 2007 to 2012 [J].
Henkle, Emily ;
Hedberg, Katrina ;
Schafer, Sean ;
Novosad, Shannon ;
Winthrop, Kevin L. .
ANNALS OF THE AMERICAN THORACIC SOCIETY, 2015, 12 (05) :642-647
[9]   Increased risk of nontuberculous mycobacterial infection in asthmatic patients using long-term inhaled corticosteroid therapy [J].
Hojo, Masayuki ;
Iikura, Motoyasu ;
Hirano, Satoshi ;
Sugiyama, Haruhito ;
Kobayashi, Nobuyuki ;
Kudo, Koichiro .
RESPIROLOGY, 2012, 17 (01) :185-190
[10]  
HUANG Y, 2020, PLOS ONE, V15