Polatuzumab Vedotin in a Patient with Refractory Burkitt Lymphoma, a Case Report

被引:1
作者
Alanzi, Meshaal [5 ,6 ]
Abu-Tineh, Mohammad [1 ]
Szabados, Lajos [2 ]
Eldean, M. Z. Sharaf [3 ]
Alatasi, Sali [3 ]
Taha, Ruba Y. [1 ]
Elkourashy, Sarah A. [1 ,4 ]
机构
[1] Hamad Med Corp, Dept Internal Med, Doha, Qatar
[2] Natl Ctr Canc Care & Res, Dept Med Oncol Hematol, Doha, Qatar
[3] Natl Ctr Canc Care & Res, Hamad Med Corp, Dept Nucl Med, Doha, Qatar
[4] Hamad Med Corp, Dept Pathol, Doha, Qatar
[5] Weill Cornell Med Univ, Doha, Qatar
[6] Hamad Med Corp, Internal Med Resident, Al Rayan Rd, Doha, Qatar
来源
ONCOTARGETS AND THERAPY | 2023年 / 16卷
关键词
Burkitt?s lymphoma; polatuzumab; Lymphoma; anti CD79b; resistant lymphoma;
D O I
10.2147/OTT.S394193
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Although Burkitt lymphoma is considered a curable disease due to the progress made in choosing the most effective first -line therapy, relapsed or refractory Burkitt lymphoma (BL) has a very poor outcome. There is a lack of data supporting the treatment regimens. We report a 48-year-old male with stage II Burkitt's lymphoma with no response to the first line of high-intensity chemotherapy. However, treatment with polatuzumab vedotin led to complete clinical remission for more than one year.
引用
收藏
页码:133 / 139
页数:7
相关论文
共 21 条
  • [1] Approved indication: B-cell lymphoma
    不详
    [J]. AUSTRALIAN PRESCRIBER, 2020, 43 (06) : 218 - 219
  • [2] Translocations involving c-myc and c-myc function
    Boxer, LM
    Dang, CV
    [J]. ONCOGENE, 2001, 20 (40) : 5595 - 5610
  • [3] Denis Burkitt and his contribution to haematology/oncology
    Coakley, Davis
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2006, 135 (01) : 17 - 25
  • [4] Crombie Jennifer, 2021, Blood, V137, P743, DOI 10.1182/blood.2019004099
  • [5] Outcomes of HIV-associated Burkitt Lymphoma in Brazil: High treatment toxicity and refractoriness rates - A multicenter cohort study
    da Silva, Wellington F.
    Marques Garibaldi, Pedro Manoel
    da Rosa, Lidiane Ines
    Bellesso, Marcelo
    Cle, Diego Villa
    Delamain, Marcia Torresan
    Rego, Eduardo Magalhaes
    Pereira, Juliana
    Rocha, Vanderson
    [J]. LEUKEMIA RESEARCH, 2020, 89
  • [6] Polatuzumab Vedotin Plus Obinutuzumab and Lenalidomide in Patients With Relapsed/Refractory Follicular Lymphoma: Primary Analysis of the Full Efficacy Population in a Phase Ib/II Trial
    Diefenbach, Catherine
    Kahl, Brad S.
    Banerjee, Lalita
    McMillan, Andrew K.
    Miall, Fiona
    Briones, Javier
    Cordoba, Raul
    Hirata, Jamie
    Chang, YiMeng
    Musick, Lisa
    Abrisqueta, Pau
    [J]. BLOOD, 2019, 134
  • [7] Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
    Dornan, David
    Bennett, Fiona
    Chen, Yvonne
    Dennis, Mark
    Eaton, Dan
    Elkins, Kristi
    French, Dorothy
    Go, Mary Ann T.
    Jack, Andrew
    Junutula, Jagath R.
    Koeppen, Hartmut
    Lau, Jeffrey
    McBride, Jacqueline
    Rawstron, Andy
    Shi, Xiaoyan
    Yu, Nancy
    Yu, Shang-Fan
    Yue, Peng
    Zheng, Bing
    Ebens, Allen
    Polson, Andrew G.
    [J]. BLOOD, 2009, 114 (13) : 2721 - 2729
  • [8] FDA, 2019, FDA APPR POL VED PII
  • [9] Novel Biological Insights and New Developments in Management of Burkitt Lymphoma and High-Grade B-Cell Lymphoma
    Lap, Coen J.
    Nassereddine, Samah
    Dunleavy, Kieron
    [J]. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2021, 22 (07)
  • [10] Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotin
    Li, Dongwei
    Lee, Donna
    Dere, Randall C.
    Zheng, Bing
    Yu, Shang-Fan
    Fuh, Franklin K.
    Kozak, Katherine R.
    Chung, Shan
    Yadav, Daniela Bumbaca
    Nazzal, Denise
    Danilenko, Dimitry
    Go, Mary Ann T.
    Williams, Marna
    Polson, Andrew G.
    Poon, Kirsten Achilles
    Prabhu, Saileta
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2019, 176 (19) : 3805 - 3818