Gut microbiota modulation via short-term administration of potential probiotic kefir yeast Kluyveromyces marxianus A4 and A5 in BALB/c mice

被引：5

作者：

Youn, Hye-Young ^{[1
]}

Kim, Hyeon-Jin ^{[1
]}

Kim, Dong-Hyeon ^{[1
]}

Jang, Yong-Seok ^{[1
]}

Kim, Hyunsook ^{[2
]}

Seo, Kun-Ho ^{[1
]}

机构：

[1] Konkuk Univ, Coll Vet Med, Ctr One Hlth, Dept Vet Publ Hlth, Seoul 05029, South Korea

[2] Hanyang Univ, Coll Human Ecol, Dept Food & Nutr, Seoul 04763, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2023年 / 32卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Kefir; Kluyveromyces marxianus; Cell adhesion; Gut microbiota; Probiotics; SACCHAROMYCES-BOULARDII; FOOD;

D O I：

10.1007/s10068-023-01268-3

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Kefir yeast, Kluyveromyces marxianus, has been evaluated for its potential probiotic properties-survivability, non-pathogenicity, and antioxidant and anti-microbial activities. However, host gut microbiota modulation of kefir yeasts remains unclear. Here, we compared kefir yeast strains K. marxianus A4 (Km A4) and K. marxianus A5 (Km A5) with Saccharomyces boulardii ATCC MYA-796 (Sb MYA-796) by investigating their adherence to colorectal adenocarcinoma (Caco-2) cells and gut microbiota modulation in BALB/c mice. The kefir yeast strains exhibited higher intestinal cell adhesion than Sb MYA-796 (p < 0.05). Bacteroidetes, Bacteroidales, and Bacteroides were more abundant in the 1 x 10(8) CFU/mL of Km A4 treatment group than in the control group (p < 0.05). Moreover, 1 x 10(8) CFU/mL of Km A5 increased Corynebacteriales and Corynebacterium compared to the 1 x 10(8) CFU/mL of Km A4 treatment group (p < 0.01). The results showed that Km A4 and Km A5 had good Caco-2 cell adhesion ability and modulated gut microbiota upon short-term administration in healthy mice.

引用

页码：589 / 598

页数：10

共 43 条

[1] Resveratrol Favors Adhesion and Biofilm Formation ofLacticaseibacillus paracasei subsp. paracaseiStrain ATCC334 [J].