Intratumoral microbiota: A new force in diagnosing and treating pancreatic cancer

被引：30

作者：

Jiang, Zhengting ^{[1
]}

Zhang, Wenjie ^{[1
]}

Zhang, Zhilin ^{[1
]}

Sha, Gengyu ^{[1
]}

Wang, Daorong ^{[2
]}

Tang, Dong ^{[2
]}

机构：

[1] Yangzhou Univ, Clin Med Coll, Yangzhou 225001, Jiangsu, Peoples R China

[2] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Inst Gen Surg, Clin Med Coll, Yangzhou 225001, Peoples R China

来源：

CANCER LETTERS | 2023年 / 554卷

关键词：

DNA damage; Tumor immune microenvironment; Biomarker; Chemotherapy; Immunotherapy; FUSOBACTERIUM-NUCLEATUM; TUMOR MICROBIOME; GUT MICROBIOTA; BACTERIA; RESISTANCE; CARCINOGENESIS; IMMUNOTHERAPY; MUTAGENESIS; MECHANISMS; EXPRESSION;

D O I：

10.1016/j.canlet.2022.216031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is an increasingly growing source of cancer-related deaths and is often diagnosed at advanced stages. Its treatment is difficult because of the poor results of conventional treatments, such as surgery, chemotherapy, and radiotherapy. Microbiota and their products can regulate the microenvironment of pancre-atic tumors, the biological behavior of pancreatic cancer cells, and the functionality of the immune system. Promising results have been achieved in treating pancreatic cancer by regulating microbiota. However, intra-tumoral microbiota is still in its infancy as a new field of discovery for pancreatic cancer. This review summarizes the mechanisms by which intratumoral microbiota causes pancreatic cancer tumorigenesis, progression, and metastasis and demonstrates their significant potential in diagnosing and treating pancreatic cancer. Addition-ally, we present an outlook on the future of intratumoral microbiota in treating pancreatic cancer.

引用

页数：10

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