Obstructive Sleep Apnea and Hypertensive Heart Disease: From Pathophysiology to Therapeutics

被引:2
|
作者
Liu, Lu [1 ]
Wang, Yi [1 ]
Hong, Liqiong [1 ]
Bragazzi, Nicola Luigi [2 ]
Dai, Haijiang [1 ]
Chen, Huimin [1 ]
机构
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Cardiol, Hangzhou 310000, Zhejiang, Peoples R China
[2] Univ Parma, Med Sch, Dept Food & Drugs, Human Nutr Unit, I-43125 Parma, Italy
关键词
obstructive sleep apnea; hypertensive heart disease; pathophysiology; therapeutics; LEFT-VENTRICULAR HYPERTROPHY; POSITIVE AIRWAY PRESSURE; CLINICAL-PRACTICE GUIDELINE; INTERMITTENT HYPOXIA; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; WEIGHT-LOSS; SEVERITY; ASSOCIATION;
D O I
10.31083/j.rcm2412342
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of complete or partial obstruction of the upper airway that lead to intermittent hypoxemia, negative intrathoracic pressure, hypercapnia, and sleep disturbances. While OSA is recognized as a significant risk factor for cardiovascular disease, it's relationship with hypertensive heart disease (HHD) remains underappreciated. HHD is a condition characterized by the pathological hypertrophy of the left ventricle, a consequence of elevated arterial hypertension. Interestingly, both OSA and HHD share similar underlying mechanisms including hypertension, left ventricular hypertrophy, myocardial fibrosis, oxidative stress, and inflammation, which ultimately contribute to the progression of HHD. This review aims to shed light on the potential role of OSA in HHD pathogenesis, summarizing current OSA treatment options. It is hoped that this review will encourage a renewed clinical focus on HHD and underscore the need for further OSA research, particularly in the context of screening and treating HHD patients.
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页数:9
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