Mitochondria perform a myriad of essential functions that ensure organismal homeostasis, including maintaining bioenergetic capacity, sensing and signalling the presence of pathogenic threats, and determining cell fate. Their function is highly dependent on mitochondrial quality control and the appropriate regulation of mitochondrial size, shape, and distribution during an entire lifetime, as well as their inheritance across generations. The roundworm Caenorhabditis elegans has emerged as an ideal model organism through which to study mitochon-dria. The remarkable conservation of mitochondrial biology has allowed C. elegans researchers to investigate complex processes that are challenging to study in higher organisms. In this review, we explore the key recent contributions of C. elegans to mitochondrial biology through the lens of mitochondrial dynamics, organellar removal, and mitochondrial inheritance, as well as their involvement in immune responses, various types of stress, and transgenerational signalling.
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Univ Washington, Ctr Dev Therapeut, Seattle, WA 98195 USAUniv Washington, Ctr Dev Therapeut, Seattle, WA 98195 USA
Morgan, Phil G.
Sedensky, Margaret M.
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Univ Washington, Ctr Dev Therapeut, Seattle, WA 98195 USAUniv Washington, Ctr Dev Therapeut, Seattle, WA 98195 USA
Sedensky, Margaret M.
Falk, Marni J.
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Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USAUniv Washington, Ctr Dev Therapeut, Seattle, WA 98195 USA
Falk, Marni J.
Kolker, Eugene
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Univ Washington, Ctr Dev Therapeut, Seattle, WA 98195 USAUniv Washington, Ctr Dev Therapeut, Seattle, WA 98195 USA
Kolker, Eugene
Higdon, Roger
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Univ Washington, Ctr Dev Therapeut, Seattle, WA 98195 USAUniv Washington, Ctr Dev Therapeut, Seattle, WA 98195 USA
Higdon, Roger
Newgard, Chris
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Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC USA
Duke Univ, Dept Biochem & Internal Med, Durham, NC USAUniv Washington, Ctr Dev Therapeut, Seattle, WA 98195 USA
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Univ Michigan, Inst Life Sci, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USAUniv Michigan, Inst Life Sci, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
Iliff, Adam J.
Xu, X. Z. Shawn
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Univ Michigan, Inst Life Sci, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USAUniv Michigan, Inst Life Sci, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
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Duke Univ, Dept Mol Genet & Microbiol, Med Ctr, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Neurobiol, Regenerat Next, Durham, NC USA
Duke Univ, Med Ctr, Duke Inst Brain Sci, Durham, NC USADuke Univ, Dept Mol Genet & Microbiol, Med Ctr, Durham, NC 27710 USA
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Nagoya Univ, Grad Sch Sci, Div Biol Sci, Grp Mol Neurobiol, Nagoya, Aichi 4648602, JapanNagoya Univ, Grad Sch Sci, Div Biol Sci, Grp Mol Neurobiol, Nagoya, Aichi 4648602, Japan