Adverse drug reactions in pregnant women: Do they differ from those in non-pregnant women of childbearing age?

被引：5

作者：

Balon, Maylis ^{[1
]}

Tessier, Samuel ^{[1
]}

Damase-Michel, Christine ^{[1
]}

Cottin, Judith ^{[2
]}

Lambert, Aude ^{[3
]}

Thompson, Marie-Andree ^{[4
]}

Benevent, Justine ^{[1
]}

Lacroix, Isabelle ^{[1
,5
]}

机构：

[1] CHU Toulouse, Ctr Reg Pharmacovigilance Pharmacoepidemiol & Info, Serv Pharmacol Med & Clin, Unite Medicaments Grossesse & Allaitement,Fac Med,, F-31000 Toulouse, France

[2] Hosp Civils Lyon, Ctr Reg Pharmacovigilance, F-69424 Lyon, France

[3] Hop Civil, Ctr Reg Pharmacovigilance, F-67091 Strasbourg, France

[4] CHU Montpellier, Ctr Reg Pharmacovigilance, Serv Pharmacol Med & Toxicol, F-34295 Montpellier, France

[5] Fac Med, Serv Pharmacol Med & Clin, 37 allees Jules Guesde, F-31000 Toulouse, France

来源：

THERAPIE | 2023年 / 78卷 / 02期

关键词：

Adverse drug reaction; Medication; Pregnant women; Pharmacokinetic; IMMUNE-SYSTEM; ANAPHYLAXIS; SAFETY; LIVER;

D O I：

10.1016/j.therap.2022.11.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacoepidemiological research in pregnant women has focused on adverse drug reactions for the course of pregnancy or for the unborn child, but little is known on the risks for the mother. We reported the results of a study that compared adverse drug reactions in preg-nant women with non-pregnant women of childbearing age, and investigated whether which types of adverse reactions were more often reported in pregnant women and which drugs were more often involved. This study was carried out in the French pharmacovigilance database (BNPV). We compared adverse drug reactions reported between 1 January 2010 and 31 December 2019 in pregnant women with those reported in of non-pregnant women of childbearing age. We cross-matched each pregnant woman with three non-pregnant women of childbearing age according to geographic area, age and year the adverse reaction was reported. Data analysis revealed that serious adverse reactions were more frequently reported in pregnant women, including anaphylactic reactions. Other adverse reactions including tachycardia, hypotension and hepatic injury were also more frequent in pregnant women than in non-pregnant women of the same age. This could be explained by physiological changes in pregnancy that lead to greater sensitivity to certain adverse reactions. Some drugs, such as phloroglucinol, metoclopramide, iron, atosiban and nifedipine, were more frequently involved in adverse reactions in pregnant women. These drugs are specifically used during pregnancy, which may explain why they are over-represented in adverse reactions. This is the first comparative descriptive study on drug adverse reactions in pregnant women. Specific epidemiological and pharmacokinetic studies are necessary to confirm these results and better understand the differences observed to improve the monitoring of pregnant women exposed to certain drugs. (c) 2022 Societe francaise de pharmacologie et de therapeutique. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：165 / 173

页数：9

共 32 条

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