Modifying superparamagnetic iron oxides nanoparticles for doxorubicin delivery carriers: a review

被引：14

作者：

Doan, Linh ^{[1
,2
]}

Nguyen, Loc T. ^{[3
]}

Nguyen, Ngan T. N. ^{[2
,4
]}

机构：

[1] Int Univ Vietnam Natl Univ, Sch Chem & Environm Engn, Ho Chi Minh City, Vietnam

[2] Int Univ Vietnam Natl Univ, Nanomat Engn Res & Dev NERD Lab, Ho Chi Minh City, Vietnam

[3] Int Univ Vietnam Natl Univ, Dept Appl Chem, Ho Chi Minh City, Vietnam

[4] Int Univ Vietnam Natl Univ, Dept Biochem, Ho Chi Minh City, Vietnam

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2023年 / 25卷 / 04期

关键词：

SPION; Iron oxide; Nanoparticles; DOX; Drug delivery carriers; Synthesis methods; Nanoscale effects; SELF-ASSEMBLED NANOPARTICLES; CORE-SHELL NANOPARTICLES; TARGETED DRUG-DELIVERY; RESPONSIVE MAGNETIC NANOPARTICLES; HYBRID HOLLOW MICROSPHERES; TOPOISOMERASE-II ACTIVITY; SIZE-CONTROLLED SYNTHESIS; SONOCHEMICAL SYNTHESIS; GRAPHENE OXIDE; FE3O4; NANOPARTICLES;

D O I：

10.1007/s11051-023-05716-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cancer-one of the most life-threatening human diseases-can be treated with surgery, chemotherapy, and radiotherapy. Despite the negative side effects, conventional chemotherapy which contains doxorubicin is widely used in cancer treatment. Drug delivery carriers, an alternative cancer treatment, can be used to target tumor site by vectorizing anti-cancer drug and minimize the drug quantities. Due to unique physical and chemical properties, superparamagnetic iron oxide nanoparticles are researched and documented. This work investigates how magnetic drug delivery carriers are synthesized, how the carriers are characterized and quantified, the mechanisms of drug loading/releasing of the carriers including kinetics and thermodynamic parameters, and the future research topics of magnetic drug delivery carriers for loading and releasing doxorubicin.

引用

页数：30

共 428 条

[41] Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy [J].