Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease

被引：6
|
作者：
Katagishi, Daiki [1 ]
Yasuda, Daisuke [1 ]
Takahashi, Kyoko [2 ]
Nakamura, Shigeo [2 ]
Mashino, Tadahiko [1 ]
Ohe, Tomoyuki [1 ]
机构：
[1] Keio Univ, Fac Pharm, Dept Pharmaceut Sci, 1-5-30 Shibakoen,Minato Ku, Tokyo, Japan
[2] Nippon Med Sch, Dept Chem, 1-7-1 Kyonan Cho,Musashino, Tokyo, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2023年 / 80卷
关键词：
Fullerene; COVID-19; SARS-CoV-2; Main protease; REVERSE TRANSCRIPTASE INHIBITION; C-60; POLYMERASE;
D O I：
10.1016/j.bmcl.2022.129121
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
COVID-19 is an ongoing worldwide pandemic. Even today, there is a need for the development of effective therapeutic agents. SARS-CoV-2 is known as the causative virus of COVID-19, and its main protease is one of the enzymes essential for its growth and is considered a drug discovery target. In this study, we evaluated the inhibitory activities of a variety of fullerene derivatives, including newly synthesized derivatives, against the main protease of SARS-CoV-2. As a result, the malonic acid-type fullerene derivatives showed the strongest inhibitory activity.
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页数：5
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