Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease

被引：6

作者：

Katagishi, Daiki ^{[1
]}

Yasuda, Daisuke ^{[1
]}

Takahashi, Kyoko ^{[2
]}

Nakamura, Shigeo ^{[2
]}

Mashino, Tadahiko ^{[1
]}

Ohe, Tomoyuki ^{[1
]}

机构：

[1] Keio Univ, Fac Pharm, Dept Pharmaceut Sci, 1-5-30 Shibakoen,Minato Ku, Tokyo, Japan

[2] Nippon Med Sch, Dept Chem, 1-7-1 Kyonan Cho,Musashino, Tokyo, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2023年 / 80卷

关键词：

Fullerene; COVID-19; SARS-CoV-2; Main protease; REVERSE TRANSCRIPTASE INHIBITION; C-60; POLYMERASE;

D O I：

10.1016/j.bmcl.2022.129121

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

COVID-19 is an ongoing worldwide pandemic. Even today, there is a need for the development of effective therapeutic agents. SARS-CoV-2 is known as the causative virus of COVID-19, and its main protease is one of the enzymes essential for its growth and is considered a drug discovery target. In this study, we evaluated the inhibitory activities of a variety of fullerene derivatives, including newly synthesized derivatives, against the main protease of SARS-CoV-2. As a result, the malonic acid-type fullerene derivatives showed the strongest inhibitory activity.

引用

页数：5

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