Fullerene derivatives as inhibitors of the SARS-CoV-2 main protease

被引：6
|
作者：
Katagishi, Daiki [1 ]
Yasuda, Daisuke [1 ]
Takahashi, Kyoko [2 ]
Nakamura, Shigeo [2 ]
Mashino, Tadahiko [1 ]
Ohe, Tomoyuki [1 ]
机构：
[1] Keio Univ, Fac Pharm, Dept Pharmaceut Sci, 1-5-30 Shibakoen,Minato Ku, Tokyo, Japan
[2] Nippon Med Sch, Dept Chem, 1-7-1 Kyonan Cho,Musashino, Tokyo, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2023年 / 80卷
关键词：
Fullerene; COVID-19; SARS-CoV-2; Main protease; REVERSE TRANSCRIPTASE INHIBITION; C-60; POLYMERASE;
D O I：
10.1016/j.bmcl.2022.129121
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
COVID-19 is an ongoing worldwide pandemic. Even today, there is a need for the development of effective therapeutic agents. SARS-CoV-2 is known as the causative virus of COVID-19, and its main protease is one of the enzymes essential for its growth and is considered a drug discovery target. In this study, we evaluated the inhibitory activities of a variety of fullerene derivatives, including newly synthesized derivatives, against the main protease of SARS-CoV-2. As a result, the malonic acid-type fullerene derivatives showed the strongest inhibitory activity.
引用
收藏
页数：5
相关论文
共 50 条
  • [1] Discovery of novel inhibitors of SARS-CoV-2 main protease
    Zheng, Lei
    Chen, Yanmei
    Bao, Jingxiao
    He, Liping
    Dong, Suzhen
    Qi, Yifei
    Zhang, John Z. H.
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (23) : 12526 - 12534
  • [2] New Thiazolidine-4-One Derivatives as SARS-CoV-2 Main Protease Inhibitors
    Messore, Antonella
    Malune, Paolo
    Patacchini, Elisa
    Madia, Valentina Noemi
    Ialongo, Davide
    Arpacioglu, Merve
    Albano, Aurora
    Ruggieri, Giuseppe
    Saccoliti, Francesco
    Scipione, Luigi
    Tramontano, Enzo
    Canton, Serena
    Corona, Angela
    Scognamiglio, Sante
    Paulis, Annalaura
    Suleiman, Mustapha
    Al-Maqtari, Helmi Mohammed
    Abid, Fatma Mohamed A.
    Kawsar, Sarkar M. A.
    Sankaranarayanan, Murugesan
    Di Santo, Roberto
    Esposito, Francesca
    Costi, Roberta
    PHARMACEUTICALS, 2024, 17 (05)
  • [3] Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors
    Khatua, Kaustav
    Alugubelli, Yugendar R.
    Yang, Kai S.
    Vulupala, Veerabhadra R.
    Blankenship, Lauren R.
    Coleman, Demonta
    Atla, Sandeep
    Chaki, Sankar P.
    Geng, Zhi Zachary
    Xiao, Jing
    Chen, Peng-Hsun
    Cho, Chia-Chuan D.
    Sharma, Shivangi
    Vatansever, Erol C.
    Ma, Yuying
    Yu, Ge
    Neuman, Benjamin W.
    Xu, Shiqing
    Liu, Wenshe Ray
    ANTIVIRAL RESEARCH, 2024, 225
  • [4] Structural Basis of Potential Inhibitors Targeting SARS-CoV-2 Main Protease
    Mengist, Hylemariam Mihiretie
    Dilnessa, Tebelay
    Jin, Tengchuan
    FRONTIERS IN CHEMISTRY, 2021, 9
  • [5] Cysteine focused covalent inhibitors against the main protease of SARS-CoV-2
    Paul, Archi Sundar
    Islam, Rajib
    Parves, Md Rimon
    Al Mamun, Abdulla
    Shahriar, Imrul
    Hossain, Md Imran
    Hossain, Md Nayeem
    Ali, Md Ackas
    Halim, Mohammad A.
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2022, 40 (04) : 1639 - 1658
  • [6] A Genetic Trap in Yeast for Inhibitors of SARS-CoV-2 Main Protease
    Alalam, Hanna
    Sigurdardottir, Sunniva
    Bourgard, Catarina
    Tiukova, Ievgeniia
    King, Ross D.
    Grotli, Morten
    Sunnerhagen, Per
    MSYSTEMS, 2021, 6 (06)
  • [7] Zinc thiotropolone combinations as inhibitors of the SARS-CoV-2 main protease
    DeLaney, Christopher
    Sheng, Yan
    Pectol, D. Chase
    Vantansever, Erol
    Zhang, Hanyuan
    Bhuvanesh, Nattamai
    Salas, Isaiah
    Liu, Wenshe R.
    Fierke, Carol F.
    Darensbourg, Marcetta Y.
    DALTON TRANSACTIONS, 2021, 50 (35) : 12226 - 12233
  • [8] Investigating the Inhibition of Diindolylmethane Derivatives on SARS-CoV-2 Main Protease
    Li, Wenjin
    Chang, Xiaoyu
    Zhou, Hang
    Yu, Wenquan
    Wang, Ruiyong
    Chang, Junbiao
    JOURNAL OF MOLECULAR RECOGNITION, 2024, 37 (06)
  • [9] Computational Prediction of Potential Inhibitors of the Main Protease of SARS-CoV-2
    Abel, Renata
    Ramos, Maria Paredes
    Chen, Qiaofeng
    Perez-Sanchez, Horacio
    Coluzzi, Flaminia
    Rocco, Monica
    Marchetti, Paolo
    Mura, Cameron
    Simmaco, Maurizio
    Bourne, Philip E.
    Preissner, Robert
    Banerjee, Priyanka
    FRONTIERS IN CHEMISTRY, 2020, 8
  • [10] Plant protease inhibitors against SARS-CoV-2 main protease: an in silico approach
    Lima, Adrianne M.
    de Souza, Adson A.
    Amaral, Jackson L.
    Freire, Valder N.
    Souza, Pedro F.
    de Oliveira, Hermogenes D.
    FUTURE VIROLOGY, 2023, 18 (07) : 439 - 454
12345