Multisystem Inflammatory Syndrome in Children Admitted to a Tertiary Pediatric Intensive Care Unit

被引:1
作者
Gun, Emrah [1 ]
Kendirli, Tanil [1 ]
Botan, Edin [1 ]
Turker, Nazmiye [2 ]
Gurbanov, Anar [1 ]
Balaban, Burak [1 ]
Gencay, Ali Genco [1 ]
Arga, Gul [3 ]
Karagozlu, Selen [4 ]
Ramoglu, Mehmet Gokhan [4 ]
Ozdemir, Halil [3 ]
Ucar, Tayfun [4 ]
Tutar, Ercan [4 ]
Ciftci, Ergin [3 ]
机构
[1] Ankara Univ Sch Med, Div Pediat Intens Care, Dept Pediat Intens Care, Ankara, Turkey
[2] Ankara Univ Sch Med, Dept Pediat, Ankara, Turkey
[3] Ankara Univ Sch Med, Dept Pediat Infect Dis, Ankara, Turkey
[4] Ankara Univ Sch Med, Dept Pediat Cardiol, Ankara, Turkey
关键词
multisystem inflammatory syndrome in children; COVID-19; children; pediatric intensive care; COVID-19;
D O I
10.1055/s-0041-1733943
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background Multisystem inflammatory syndrome in children (MIS-C) is characterized by persistent fever, abdominal pain, vomiting, diarrhea, rash, conjunctivitis, headaches, and mucocutaneous manifestations and it can cause circulatory dysfunction, resulting in hypotension, shock, and end-organ injury in the heart and other organs and possibly death. In this study, we aimed to analyze the clinical spectrum, treatment options and outcomes of children with MIS-C who were admitted to our pediatric intensive care (PICU). Materials and Methods Clinical and laboratory findings and treatment of the patients admitted to the PICU with MIS-C between April 2020 and January 2021 were recorded, and their outcomes were evaluated. Results Nineteen patients with a median age of 12.5 years (interquartile range (IQR): 5.8-14.0 years) were admitted. Eleven (57.8%) were males. The most frequent clinical and laboratory features were fever (100%), abdominal pain (94.7%), rash (63.1%), headache (68.4%), diarrhea (47.3%), seizure (10.5%), cardiac dysfunction (52.6%), acute kidney injury (26.3%), lymphopenia (84.2%), and thrombocytopenia (36.8%). However, 8 patients needed mechanical respiratory support, 11 patients needed inotropes, 2 patients needed plasma exchange, and 1 patient needed continuous renal replacement therapy. All patients received corticosteroids, 17 patients (89.2%) received intravenous immunoglobulin, 2 patients received anakinra, 10 patients received acetylsalicylic acid, and 6 patients received enoxaparin. Median PICU length of stay was 3 days (IQR: 2-5) and only one patient died. Conclusion In conclusion, MIS-Cmay present with a variety of clinicalmanifestations, and it can lead to life-threatening critical illness. Most children need intensive care and the response to immunomodulation is usually favorable.
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收藏
页码:37 / 43
页数:7
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