Stink bean (Parkia speciosa) empty pod: a potent natural antidiabetic agent for the prevention of pancreatic and hepatorenal dysfunction in high fat diet/streptozotocin-induced type 2 diabetes in rats

被引：16

作者：

Gao, Liwei ^{[1
]}

Zhang, Wenzhi ^{[2
]}

Yang, Leiyan ^{[2
]}

Fan, Hong ^{[3
]}

Olatunji, Opeyemi Joshua ^{[4
]}

机构：

[1] Danyang Peoples Hosp Jiangsu Prov, Dept Cardiovasc Med, Danyang, Jiangsu, Peoples R China

[2] Innosci Res Sdn Bhd, Subang Jaya, Selangor, Malaysia

[3] Changzhi Med Coll, Dept Endocrinol, Peace Hosp, Changzhi 046000, Shanxi, Peoples R China

[4] Prince Songkla Univ, Fac Thai Tradit Med, Hat Yai, Thailand

来源：

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY | 2023年 / 129卷 / 01期

关键词：

Parkia speciosa; diabetes; oxidative stress; antioxidant; polyphenols; streptozotocin; OXIDATIVE STRESS; HYPERGLYCEMIA;

D O I：

10.1080/13813455.2021.1876733

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study investigated the effect of polyphenol-rich extract of Parkia speciosa (PPS) against pancreatic and hepatorenal dysfunction in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetes. Diabetic rats were treated with PPS (100 and 400 mg/kg) and glibenclamide. The results revealed that diabetic rats displayed marked hyperglycaemia, hyperlipidaemia, hypoinsulinemia as well as alterations in serum renal and kidney function markers. Furthermore, diabetic rats showed significant increase in hepatorenal level of malonaldehyde as well as suppression of antioxidant enzyme activities. Whereas, diabetic rats that received PPS displayed marked attenuation in most of the aforementioned parameters compared to the untreated diabetic rats. Additionally, histological examination revealed restoration of histopathological alterations of the pancreas, liver, and kidney of PPS treated diabetic rats. In conclusion, the results demonstrated that PPS could decrease serum lipids and blood glucose level, enhance insulin level and hepatorenal antioxidant capacity, as well as ameliorate hepatorenal dysfunction in rats.

引用

页码：261 / 267

页数：7

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