Review on the Role of IRF6 in the Pathogenesis of Non-syndromic Orofacial Clefts

被引：1

作者：

Di Zhang, Si ^{[1
,2
,3
]}

You, Yue ^{[1
,2
,3
]}

Yao, Mei Lin ^{[1
,2
,3
]}

Shi, Bing ^{[1
,2
,3
]}

Jia, Zhong Lin ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, 14,3rd Sect,Renmin Nan Rd, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu, Peoples R China

[3] Sichuan Univ, West China Hosp Stomatol, Dept cleft lip & palate, Chengdu, Peoples R China

来源：

CHINESE JOURNAL OF DENTAL RESEARCH | 2024年 / 27卷 / 01期

关键词：

IRF6; genetics; non-syndromic orofacial cleft (NSOC); REGULATORY FACTOR 6; IRF6 GENE VARIANTS; MISSING HERITABILITY; LINKAGE DISEQUILIBRIUM; BINDING-SITE; LIP; PALATE; ASSOCIATION; RISK; POLYMORPHISMS;

D O I：

10.3290/j.cjdr.b5128515

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Non-syndromic orofacial clefts (NSOCs) are the most common craniofacial malformation. In the complex aetiology and pathogenesis of NSOCs, genetic factors play a crucial role and IRF6, located at chromosome 1q32.2, is the best documented NSOC susceptibility gene. IRF6 is a key factor in oral maxillofacial development and known to contribute the most in NSOCs. It is essential to conduct a complete review of the existing results on IRF6 to further understand its role in the pathogenesis of NSOCs. Thus, the present authors summarised the research progress on the mechanism of IRF6 in NSOCs from both genetic and functional perspectives in this review.

引用

页码：29 / 38

页数：10

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