Visible-Light-Promoted Metal- and Photocatalyst-Free Reactions between Arylglyoxylic Acids and Tetraalkylthiuram Disulfides: Synthesis of α-Ketoamides

被引：10

作者：

Sarkar, Subhankar ^{[1
]}

Pal, Satyajit ^{[1
]}

Mukherjee, Anindita ^{[2
]}

Santra, Sougata ^{[2
]}

Zyryanov, Grigory V. ^{[2
,3
]}

Majee, Adinath ^{[1
]}

机构：

[1] Visva Bharati, Dept Chem, Santini Ketan 731235, India

[2] Ural Fed Univ, Chem Engn Inst, Dept Organ & Biomol Chem, Ekaterinburg 620002, Russia

[3] Russian Acad Sci, Ural Div, IYa Postovskiy Inst Organ Synth, Ekaterinburg 620219, Russia

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 03期

关键词：

C-N; COUPLING REACTIONS; GENERAL-APPROACH; CYCLIZATION; SOLVENTS; REAGENT;

D O I：

10.1021/acs.joc.3c02081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient and new synthetic approach has been developed for the oxidative cross-coupling of the C-N bond through the reaction between arylglyoxylic acids and tetraalkylthiuram disulfides. The reaction proceeds under ambient air at room temperature in the presence of visible light. This reaction offers a metal-, base-, photocatalyst-, and solvent-free synthesis of various alpha-ketoamides with moderate to excellent yields via the radical pathway. In addition, this protocol demonstrates the potential application of a gram-scale synthesis.

引用

页码：1473 / 1482

页数：10

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