K2S2O8-Mediated Radical Cascade Alkylation/Cyclization of Ynones: Access to Oxoalkyl-Substituted Indenones

被引：2

作者：

Tian, Si-Wei ^{[1
]}

Xiong, Fang-Ting ^{[1
]}

Xiong, Bi-Quan ^{[1
]}

Zhong, Long-Jin ^{[1
]}

Tang, Ke-Wen ^{[1
]}

Liu, Yu ^{[1
]}

机构：

[1] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Peoples R China

来源：

CHEMISTRYSELECT | 2023年 / 8卷 / 31期

基金：

中国国家自然科学基金;

关键词：

oxidative; alkylation; cyclization; indenones; radical; C(sp(3))-H bonds; C-H FUNCTIONALIZATION; CATALYZED ANNULATION; ALKYNES; CYCLIZATION; ALKYLATION; KETONES; ACETONE; ALKANES; DESIGN; BONDS;

D O I：

10.1002/slct.202302484

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient oxidative-promoted radical cascade annulation of ynone derivatives with ketones for the construction of a series of oxoalkyl-substituted indenones in moderate to good yields is described. The control experiment results indicate that the oxidative acetmethylation/arylation of ynone derivatives involves a radical cascade cyclization process. This is an operationally simple and efficient protocol which will be attractive in organic synthesis chemistry.

引用

页数：5

共 77 条

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