Synthesis and biological evaluation of some substituted pyrazolopyrimidines derivatives as potential α-glucosidase inhibitors

Present communication deals with the synthesis of a novel series of substituted ethyl 6-substituted (2-phenyldiazenyl)-4,5-dihydro-7-methylpyrazolo[1,5-a]pyrimidine-5-carboxylate compounds were synthesized and evaluated for invitro a-glucosidase inhibitory activity embracing pyrazolopyrimidines nucleus in their moiety. The compounds were synthesized in excellent yields and their structures were collaborated on the basis of FT-IR, 1H NMR, and mass analyses data. Their purity has been ascertained by thin layer chromatographic method. The maximum alpha-glucosidase inhibitory activity was reported with 3c, 3d, 3g, 3i and 3k, with inhibition 82.96%, 88.37%, 85.79%, 89.43% and 94.61%, respectively.