Cardio-oncology: Shared Genetic, Metabolic, and Pharmacologic Mechanism

被引：2

作者：

Zhao, Yiqi ^{[1
,2
]}

Jia, Hao ^{[1
,2
]}

Hua, Xiumeng ^{[1
,2
]}

An, Tao ^{[3
]}

Song, Jiangping ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Anim Expt Ctr,Beijing Key Lab Preclin Res & Evalua, Beijing, Peoples R China

[2] Chinese Acad Med Sci, Fuwai Hosp, State Key Lab Cardiovasc Dis, PUMC, 167 Beilishi Rd, Beijing 100037, Peoples R China

[3] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Dept Cardiac Surg, Beijing, Peoples R China

来源：

CURRENT CARDIOLOGY REPORTS | 2023年 / 25卷 / 08期

关键词：

Cardio-oncology; Gene mutation; Metabolism; Cardiotoxicity; RECEPTOR KINASE 4; NF-KAPPA-B; HEART-FAILURE; CARDIOVASCULAR-DISEASE; CLONAL HEMATOPOIESIS; ANTHRACYCLINE CARDIOTOXICITY; DIABETIC CARDIOMYOPATHY; PRIMARY PREVENTION; PDE5; INHIBITORS; IN-VIVO;

D O I：

10.1007/s11886-023-01906-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewThe article aims to investigate the complex relationship between cancer and cardiovascular disease (CVD), with a focus on the effects of cancer treatment on cardiac health.Recent FindingsAdvances in cancer treatment have improved long-term survival rates, but CVD has emerged as a leading cause of morbidity and mortality in cancer patients. The interplay between cancer itself, treatment methods, homeostatic changes, and lifestyle modifications contributes to this comorbidity. Recent research in the field of cardio-oncology has revealed common genetic mutations, risk factors, and metabolic features associated with the co-occurrence of cancer and CVD.This article provides a comprehensive review of the latest research in cardio-oncology, including common genetic mutations, risk factors, and metabolic features, and explores the interactions between cancer treatment and CVD drugs, proposing novel approaches for the management of cancer and CVD.

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页码：863 / 878

页数：16

相关论文

共 150 条

[1] DNA methylation processes in atheosclerotic plaque [J].

Aavik, Einari ;

Babu, Mohan ;

Yla-Herttuala, Seppo .

ATHEROSCLEROSIS, 2019, 281 :168-179

[2] A Population-Based Study of Cardiovascular Mortality Following Early-Stage Breast Cancer [J].

Abdel-Qadir, Husam ;

Austin, Peter C. ;

Lee, Douglas S. ;

Amir, Eitan ;

Tu, Jack V. ;

Thavendiranathan, Paaladinesh ;

Fung, Kinwah ;

Anderson, Geoffrey M. .

JAMA CARDIOLOGY, 2017, 2 (01) :88-93

[3] Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure [J].

Abplanalp, Wesley Tyler ;

Mas-Peiro, Silvia ;

Cremer, Sebastian ;

John, David ;

Dimmeler, Stefanie ;

Zeiher, Andreas M. .

JAMA CARDIOLOGY, 2020, 5 (10) :1170-1175

[4] SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes [J].

Agarwal, Nitin ;

Taberner, Francisco J. ;

Rojas, Daniel Rangel ;

Moroni, Mirko ;

Omberbasic, Damir ;

Njoo, Christian ;

Andrieux, Alexandra ;

Gupta, Pooja ;

Bali, Kiran K. ;

Herpel, Esther ;

Faghihi, Faramarz ;

Fleming, Thomas ;

Dejean, Anne ;

Lechner, Stefan G. ;

Nawroth, Peter P. ;

Lewin, Gary R. ;

Kuner, Rohini .

NEURON, 2020, 107 (06) :1141-+

[5] Aging and Risk of Severe, Disabling, Life-Threatening, and Fatal Events in the Childhood Cancer Survivor Study [J].

Armstrong, Gregory T. ;

Kawashima, Toana ;

Leisenring, Wendy ;

Stratton, Kayla ;

Stovall, Marilyn ;

Hudson, Melissa M. ;

Sklar, Charles A. ;

Robison, Leslie L. ;

Oeffinger, Kevin C. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (12) :1218-+

[6] Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance [J].

Aroor, Annayya R. ;

McKarns, Susan ;

DeMarco, Vincent G. ;

Jia, Guanghong ;

Sowers, James R. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2013, 62 (11) :1543-1552

[7] Carvedilol for Prevention of Chemotherapy-Related Cardiotoxicity [J].

Avila, Monica Samuel ;

Ayub-Ferreira, Silvia Moreira ;

de Barros Wanderley, Mauro Rogerio, Jr. ;

Cruz, Fatima das Dores ;

Goncalves Brandao, Sara Michelly ;

Carvalho Rigaud, Vagner Oliveira ;

Higuchi-dos-Santos, Marilia Harumi ;

Hajjar, Ludhmila Abrahao ;

Kalil Filho, Roberto ;

Hoff, Paulo Marcelo ;

Sahade, Marina ;

Ferrari, Marcela S. M. ;

de Paula Costa, Romulo Leopoldo ;

Mano, Max Senna ;

Bittencourt Viana Cruz, Cecilia Beatriz ;

Abduch, Maria Cristina ;

Lofrano Alves, Marco Stephan ;

Guimaraes, Guilherme Veiga ;

Issa, Victor Sarli ;

Bittencourt, Marcio Sommer ;

Bocchi, Edimar Alcides .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 71 (20) :2281-2290

[8] A wake-up call to quiescent cancer cells - potential use of DYRK1B inhibitors in cancer therapy [J].

Becker, Walter .

FEBS JOURNAL, 2018, 285 (07) :1203-1211

[9] Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer [J].

Bellahcene, Akeila ;

Nokin, Marie-Julie ;

Castronovo, Vincent ;

Schalkwijk, Casper .

SEMINARS IN CANCER BIOLOGY, 2018, 49 :64-74

[10] Impact of Clonal Hematopoiesis in Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction [J].

Boehme, Matthias ;

Desch, Steffen ;

Rosolowski, Maciej ;

Scholz, Markus ;

Krohn, Knut ;

Buettner, Petra ;

Cross, Michael ;

Kirchberg, Janine ;

Rommel, Karl-Philipp ;

Poess, Janine ;

Freund, Anne ;

Baber, Ronny ;

Isermann, Berend ;

Ceglarek, Uta ;

Metzeler, Klaus H. ;

Platzbecker, Uwe ;

Thiele, Holger .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2022, 80 (16) :1545-1556

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