Base-Promoted 1,6-Aza-Michael Addition of Azauracils to para -Quinone Methides

被引：4

作者：

Dash, Rupashri ^{[1
]}

Hota, Sudhir Kumar ^{[1
]}

Murarka, Sandip ^{[1
]}

机构：

[1] Indian Inst Technol Jodhpur, Dept Chem, Karwar 342037, Rajasthan, India

来源：

SYNTHESIS-STUTTGART | 2024年 / 56卷 / 04期

关键词：

azauracil; para-quinone methides; 1,6-addition; aza-Michael; metal-free; CATALYTIC 1,6-CONJUGATE ADDITION/AROMATIZATION; ENANTIOSELECTIVE SYNTHESIS; EXPEDIENT ACCESS; METAL-FREE; 1,6-ADDITION; DERIVATIVES; ALKYLATION; AROMATIZATION; ESTERS; ACID;

D O I：

10.1055/a-2104-5943

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report an efficient higher order conjugate addition of azauracils to substituted para-quinone methides (p-QMs) mediated by triethylamine to furnish hitherto unknown diarylmethane scaffolds through construction of a C-N bond. The protocol features mild conditions, high atom economy, and broad scope, and enables convenient access to biologically relevant new chemical entities (NCEs) comprised of p-QM and azauracil hybrids in good to excellent yields.

引用

页码：677 / 685

页数：9

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