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Estimating the heating of complex nanoparticle aggregates for magnetic hyperthermia
被引:9
作者:
Ortega-Julia, Javier
[1
,3
]
Ortega, Daniel
[1
,2
,3
]
Leliaert, Jonathan
[4
]
机构:
[1] Fac Sci, Condensed Matter Phys Dept, Campus Univ Rio San Pedro s n, Cadiz 11510, Spain
[2] IMDEA Nanosci, Faraday 9, Madrid 28049, Spain
[3] Univ Cadiz, Inst Res & Innovat Biomed Sci Prov Cadiz INiB, Cadiz 11009, Spain
[4] Univ Ghent, Dept Solid State Sci, Ghent, Belgium
来源:
关键词:
IRON-OXIDE NANOPARTICLES;
FIELD;
ABSORPTION;
MORPHOLOGY;
FREQUENCY;
D O I:
10.1039/d3nr01269g
中图分类号:
O6 [化学];
学科分类号:
0703 ;
摘要:
Understanding and predicting the heat released by magnetic nanoparticles is central to magnetic hyperthermia treatment planning. In most cases, nanoparticles form aggregates when injected in living tissues, thereby altering their response to the applied alternating magnetic field and preventing the accurate prediction of the released heat. We performed a computational analysis to investigate the heat released by nanoparticle aggregates featuring different sizes and fractal geometry factors. By digitally mirroring aggregates seen in biological tissues, we found that the average heat released per particle stabilizes starting from moderately small aggregates, thereby facilitating making estimates for their larger counterparts. Additionally, we studied the heating performance of particle aggregates over a wide range of fractal parameters. We compared this result with the heat released by non-interacting nanoparticles to quantify the reduction of heating power after being instilled into tissues. This set of results can be used to estimate the expected heating in vivo based on the experimentally determined nanoparticle properties.
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页码:10342 / 10350
页数:9
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