Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota

被引：468

作者：

Fusco, William ^{[1
,2
]}

Lorenzo, Manuel Bernabeu ^{[3
]}

Cintoni, Marco ^{[2
,4
]}

Porcari, Serena ^{[1
,2
]}

Rinninella, Emanuele ^{[2
,4
]}

Kaitsas, Francesco ^{[1
,2
]}

Lener, Elena ^{[1
,2
]}

Mele, Maria Cristina ^{[2
,4
]}

Gasbarrini, Antonio ^{[1
,2
]}

Collado, Maria Carmen ^{[3
]}

Cammarota, Giovanni ^{[1
,2
]}

Ianiro, Gianluca ^{[1
,2
]}

机构：

[1] Univ Policlin Agostino Gemelli Fdn IRCCS, Digest Dis Ctr, Dept Med & Surg Sci, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy

[3] Food Technol Natl Res Council IATA CSIC, Inst Agrochem & Foodtechnol, Valencia 46022, Spain

[4] Univ Policlin Agostino Gemelli Fdn IRCCS, Dept Med & Surg Sci, Clin Nutr Unit, I-00168 Rome, Italy

来源：

NUTRIENTS | 2023年 / 15卷 / 09期

关键词：

gut microbiota; short-chain fatty acids; SCFA-producing bacteria; gut health; prebiotics; probiotics; diet; PROTEIN-COUPLED RECEPTOR; DOUBLE-BLIND; ARABINOXYLAN OLIGOSACCHARIDES; GASTROINTESTINAL HEALTH; METABOLITE BUTYRATE; ULCERATIVE-COLITIS; ENTERAL NUTRITION; BLOOD-PRESSURE; MUCUS BARRIER; BODY-WEIGHT;

D O I：

10.3390/nu15092211

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis and their deficiency is involved in the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, and cardiometabolic disorders. SCFAs are metabolites of specific bacterial taxa of the human gut microbiota, and their production is influenced by specific foods or food supplements, mainly prebiotics, by the direct fostering of these taxa. This Review provides an overview of SCFAs' roles and functions, and of SCFA-producing bacteria, from their microbiological characteristics and taxonomy to the biochemical process that lead to the release of SCFAs. Moreover, we will describe the potential therapeutic approaches to boost the levels of SCFAs in the human gut and treat different related diseases.

引用

页数：22

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