Comprehensive assessment of osteoporosis in lumbar spine using compositional MR imaging of trabecular bone

被引:4
作者
Liu, Jin [1 ]
Chen, Jian-Di [2 ]
Li, Ping [3 ,4 ]
Liao, Jian-Wei [1 ]
Feng, Jia-Xin [1 ]
Chen, Zi-Yang [4 ,5 ]
Cai, Zhi-Yuan [3 ]
Li, Wei [1 ]
Chen, Xiao-Jun [1 ]
Su, Zhi-Hai [5 ]
Lu, Hai [5 ]
Li, Shao-Lin [1 ,3 ,4 ]
Ma, Ya-Jun [6 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Radiol, Zhuhai 519000, Guangdong, Peoples R China
[2] Jinan Univ, Affiliated Hosp 1, Dept Radiol, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat sen Univ, Guangdong Prov Key Lab Biomed Imaging, Zhuhai, Peoples R China
[4] Sun Yat sen Univ, Affiliated Hosp 5, Guangdong Prov Engn Res Ctr Mol Imaging, Zhuhai, Peoples R China
[5] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Spinal Surg, Zhuhai, Guangdong, Peoples R China
[6] Univ Calif San Diego, Dept Radiol, 9452 Med Ctr Dr, La Jolla, CA 92037 USA
基金
中国国家自然科学基金;
关键词
Osteoporosis; Magnetic resonance imaging; Trabecular bone; Bone density; CORTICAL BONE; BOUND WATER; PORE-WATER; MARROW PERFUSION; FAT; TOUGHNESS; DENSITY; MEN; AGE;
D O I
10.1007/s00330-022-09368-0
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objectives To comprehensively assess osteoporosis in the lumbar spine, a compositional MR imaging technique is proposed to quantify proton fractions for all the water components as well as fat in lumbar vertebrae measured by a combination of a 3D short repetition time adiabatic inversion recovery prepared ultrashort echo time (STAIR-UTE) MRI and IDEAL-IQ. Methods A total of 182 participants underwent MRI, quantitative CT, and DXA. Lumbar collagen-bound water proton fraction (CBWPF), free water proton fraction (FWPF), total water proton fraction (TWPF), bone mineral density (BMD), and T-score were calculated in three vertebrae (L2-L4) for each subject. The correlations of the CBWPF, FWPF, and TWPF with BMD and T-score were investigated respectively. A comprehensive diagnostic model combining all the water components and clinical characteristics was established. The performances of all the water components and the comprehensive diagnostic model to discriminate between normal, osteopenia, and osteoporosis cohorts were also evaluated using receiver operator characteristic (ROC). Results The CBWPF showed strong correlations with BMD (r = 0.85, p < 0.001) and T-score (r = 0.72, p < 0.001), while the FWPF and TWPF showed moderate correlations with BMD (r = 0.65 and 0.68, p < 0.001) and T-score (r = 0.47 and 0.49, p < 0.001). The high area under the curve values obtained from ROC analysis demonstrated that CBWPF, FWPF, and TWPF have the potential to differentiate the normal, osteopenia, and osteoporosis cohorts. At the same time, the comprehensive diagnostic model shows the best performance. Conclusions The compositional MRI technique, which quantifies CBWPF, FWPF, and TWPF in trabecular bone, is promising in the assessment of bone quality. Key Points Compositional MR imaging technique is able to quantify proton fractions for all the water components (i.e., collagen-boundwater proton fraction (CBWPF), free water proton fraction (FWPF), and total water proton fraction (TWPF)) in the humanlumbar spine. The biomarkers derived from the compositional MR imaging technique showed moderate to high correlations with bonemineral density (BMD) and T-score and showed good performance in distinguishing people with different bone mass. The comprehensive diagnostic model incorporating CBWPF, FWPF, TWPF, and clinical characteristics showed the highestclinical diagnostic capability for the assessment of osteoporosis
引用
收藏
页码:3995 / 4006
页数:12
相关论文
共 36 条
[1]   Quantification of Human Cortical Bone Bound and Free Water in Vivo with Ultrashort Echo Time MR Imaging: A Model-based Approach [J].
Abbasi-Rad, Shahrokh ;
Rad, Hamidreza Saligheh .
RADIOLOGY, 2017, 283 (03) :861-871
[2]   Quantification of bone marrow fat content using iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL): reproducibility, site variation and correlation with age and menopause [J].
Aoki, Takatoshi ;
Yamaguchi, Shinpei ;
Kinoshita, Shunsuke ;
Hayashida, Yoshiko ;
Korogi, Yukunori .
BRITISH JOURNAL OF RADIOLOGY, 2016, 89 (1065)
[3]   Evaluation of bound and pore water in cortical bone using ultrashort-TE MRI [J].
Chen, Jun ;
Grogan, Shawn P. ;
Shao, Hongda ;
D'Lima, Darryl ;
Bydder, Graeme M. ;
Wu, Zhihong ;
Du, Jiang .
NMR IN BIOMEDICINE, 2015, 28 (12) :1754-1762
[4]   Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: The 2007 ISCD Official Positions [J].
Engelke, Klaus ;
Adams, Judith E. ;
Armbrecht, Gabriele ;
Augat, Peter ;
Bogado, Cesar E. ;
Bouxsein, Mary L. ;
Felsenberg, Dieter ;
Ito, Masako ;
Prevrhal, Sven ;
Hans, Didier B. ;
Lewiecki, E. Michael .
JOURNAL OF CLINICAL DENSITOMETRY, 2008, 11 (01) :123-162
[5]   Compromised bone marrow perfusion in osteoporosis [J].
Griffith, James F. ;
Yeung, David K. W. ;
Tsang, Polly H. ;
Choi, Kai C. ;
Kwok, Timothy C. Y. ;
Ahuja, Anil T. ;
Leung, Kwok S. ;
Leung, Ping C. .
JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 (07) :1068-1075
[6]   Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: Dynamic contrast-enhanced MR imaging and spectroscopy [J].
Griffith, JF ;
Yeung, DKW ;
Antonio, GE ;
Lee, FKH ;
Hong, AWL ;
Wong, SYS ;
Lau, EMC ;
Leung, PC .
RADIOLOGY, 2005, 236 (03) :945-951
[7]   Vertebral bone marrow fat content in normal adults with varying bone densities at 3T magnetic resonance imaging [J].
He, Jie ;
Fang, Hao ;
Li, Xiaona .
ACTA RADIOLOGICA, 2019, 60 (04) :509-515
[8]   Clinically compatible MRI strategies for discriminating bound and pore water in cortical bone [J].
Horch, R. Adam ;
Gochberg, Daniel F. ;
Nyman, Jeffry S. ;
Does, Mark D. .
MAGNETIC RESONANCE IN MEDICINE, 2012, 68 (06) :1774-1784
[9]   Non-invasive Predictors of Human Cortical Bone Mechanical Properties: T2-Discriminated 1H NMR Compared with High Resolution X-ray [J].
Horch, R. Adam ;
Gochberg, Daniel F. ;
Nyman, Jeffry S. ;
Does, Mark D. .
PLOS ONE, 2011, 6 (01)
[10]   Characterization of 1H NMR Signal in Human Cortical Bone for Magnetic Resonance Imaging [J].
Horch, R. Adam ;
Nyman, Jeffry S. ;
Gochberg, Daniel F. ;
Dortch, Richard D. ;
Does, Mark D. .
MAGNETIC RESONANCE IN MEDICINE, 2010, 64 (03) :680-687