Apoptotic Switch in Cancer Stem Cells: A Potential Approach for Cancer Treatment

被引：1
作者：
Gunasekaran, Vinoth Prasanna [1 ]
Sivaraman, Thirunavukkarasu [2 ]
Ganeshan, Mathan [3 ]
机构：
[1] Amity Univ, Amity Inst Biotechnol AIB, Ctr Drug Discovery & Dev, Mumbai 410206, Maharashtra, India
[2] Dhanalakshmi Srinivasan Grp Inst, Dhanalakshmi Srinivasan Engn Coll, Dept Chem & Res & Dev Cell, Perambalur 621212, Tamil Nadu, India
[3] Bharathidasan Univ, Dept Biomed Sci, Tiruchirapalli 620012, Tamil Nadu, India
来源：
CURRENT PROTEIN & PEPTIDE SCIENCE | 2023年 / 24卷 / 10期
关键词：
Apoptosis; anti-apoptotic proteins; cancer stem cells; biomarkers; cancers; cell death; druggable targets; proteomics; BCL-2 FAMILY PROTEINS; BH3; MIMETICS; BREAST-CANCER; EXPRESSION; BH3-MIMETICS; ANTAGONISTS; INHIBITOR; RECOGNITION; LYMPHOMA; TARGET;
D O I：
10.2174/1389203724666230512111755
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer diseases account for about 15% of deaths globally right now, and the percentage may increase in the future. There are more than 100 types of cancer, and each of them is distinct in its origin, microenvironment, growth, metastasis, and signalling pathways. Cancer stem cells are the specialised cells that make cancer more aggressive and difficult to treat. Moreover, cancer aetiology may exist at the genomic, proteomic, or habitat level in any combination. Hence, a unanimous treatment protocol for the different cancers is an uphill task at the present juncture. In this context, this review aims to provide a comprehensive reappraisal concisely of anti-apoptotic proteins, which are shown to be overexpressed in most cancers, if not all, and to forthrightly rationalise the apoptotic proteins as potential biomarkers and druggable targets of the cancers by effectively killing cancer stem cells.
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收藏
页码：843 / 852
页数：10
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