Evaluation of clinical and laboratory findings in adolescents diagnosed with polycystic ovary syndrome

Aim: Polycystic ovary syndrome (PCOS) is a heterogeneous condition characterized by menstrual irregularities, hyperandrogenism, obesity, hirsutism, and psychological and psychosexual morbidity. This study aims to investigate the relationship between clinical, anthropometric, laboratory and ultrasonography findings in adolescents with the diagnosis of PCOS. Material and Methods: Forty-one adolescent girls who were admitted to the Pediatric Endocrinology Clinic of Adana City Training and Research Hospital between January 2020 and December 2021 and diagnosed with PCOS according to the Rotterdam criteria were included in this retrospective cross-sectional study. Demographic data, hormonal and biochemical analysis of the patients were obtained from the files. Results: The mean age of admission of the patients was 15.62 +/- 1.43 years, and the mean age at first menarche was 11.98 +/- 1.32 years. Oligomenorrhea (90.2%) was the most common admission complaint. Comparing the groups with PCOS with and without hirsutism, a significant difference was found in inhibin-B level (66 +/- 45 ng/dl vs 107 +/- 37 ng/dl; p=0.038). When comparing the groups with and without ultrasound findings compatible with PCOS, a significant difference was found in AMH level. (11.0 +/- 7.3 mcg/L vs 5.9 +/- 2.8 mcg/L; p=0.032). When overweight or obese patients with PCOS were compared with the normal weight group, the difference was significant in HOMA-IR (5.0 +/- 6.2 vs 1.5 +/- 0.65; p=0.009) and first menstrual age (11.3 +/- 1.3 years vs 12.7 +/- 0.75 years; p=0.008). Discussion: In this study, while low inhibin-B was more common in patients with PCOS with hirsutism, AMH was found to be significantly higher in the group whose ultrasound findings were compatible with PCOS. These parameters can be investigated in the diagnosis of adolescent PCOS.