EFFECTS OF TRANSCRANIAL DIRECT CURRENT STIMULATION FOLLOWED BY TREADMILL TRAINING ON DUAL-TASK WALKING AND CORTICAL ACTIVITY IN CHRONIC STROKE: A DOUBLE-BLINDED RANDOMIZED CONTROLLED TRIAL

Objective: To explore the effects of transcranial direct current stimulation followed by treadmill training on dual-task gait performance and contra-lesional cortical activity in chronic stroke patients.Methods: Forty-five chronic stroke participants were randomized into 3 groups: a bilateral trans -cranial direct current stimulation and treadmill training group; a cathodal transcranial direct cur-rent stimulation and treadmill training group; and a sham transcranial direct current stimulation and treadmill training group for 50 min per session (20 min transcranial direct current stimulation fol-lowed by 30 min treadmill training), 3 sessions per week for 4 weeks. Outcome measures included cog-nitive dual-task walking, motor dual-task walking, walking performance, contralesional cortical acti-vity, and lower-extremity motor control. Results: The cathodal transcranial direct cur-rent stimulation + treadmill training group showed significantly greater improvements in cognitive dual-task walking speed than the other groups (pcathodal vs sham = 0.006, pcathodal vs bilateral = 0.016). In the cathodal transcranial direct current stimula-tion + treadmill training group the silent period duration increased significantly more than in the other groups (p < 0.05). Changes in motor evoked potentials in the cathodal transcranial direct current stimulation + treadmill training group were greater than those in the sham transcranial direct current stimulation + treadmill training group (p < 0.05). No significant changes were observed in the bilateral transcranial direct current stimulation + treadmill training group.Conclusion: Cathodal transcranial direct current sti-mulation followed by treadmill training is an effec-tive intervention for improving cognitive dual-task walking and modulating contralesional cortical activity in chronic stroke. No beneficial effects were observed after bilateral transcranial direct current stimulation and treadmill training.