Chicken-origin Cluster 3.2 Tembusu virus exhibits higher infectivity than duck-origin Cluster 2 Tembusu virus in chicks

被引:5
|
作者
Huang, Yunzhen [1 ,2 ]
Hu, Ziqiang [3 ]
Dong, Jiawen [1 ,2 ,4 ]
Li, Linlin [1 ,2 ,4 ,5 ]
Zhang, Junqin [1 ,2 ,4 ]
Kuang, Ruihuan [1 ,2 ]
Gao, Shimin [3 ]
Sun, Minhua [1 ,2 ,4 ,5 ]
Liao, Ming [1 ,2 ,4 ,5 ]
机构
[1] Guangdong Acad Agr Sci, Inst Anim Hlth, Guangzhou, Peoples R China
[2] Key Lab Livestock Dis Prevent & Treatment Guangdon, Guangzhou, Peoples R China
[3] Shanxi Agr Univ, Coll Vet Med, Taigu, Peoples R China
[4] Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China
[5] Minist Agr & Rural Affairs, Key Lab Prevent & Control Avian Influenza & Other, Guangzhou, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
tembusu virus; egg-drop syndrome; infectivity; pathogenicity; chicks; GEESE;
D O I
10.3389/fvets.2023.1152802
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
In 2020, a chicken-origin Cluster 3 Tembusu virus (TMUV) caused outbreaks of a disease characterized by egg-drop syndrome in laying hens in China. In the present study, a TMUV strain, TMUV-GX, was isolated from tissue samples of laying hens with egg drop syndrome in south China. Phylogenetic analysis grouped TMUV-GX into TMUV Cluster 3.2, which was distinct from the prevalent TMUV Cluster 2 in duck flocks. To study the infectivity and pathogenicity of TMUV-GX in chickens and ducks, 7 day-old specific pathogen-free (SPF) chicks and SPF ducklings were infected with the same dose of the TMUV-GX. As a comparison, the duck-origin Cluster 2 strain, TMUV-JM, infection groups were set up in chicks and ducklings. Compared with the low infectivity and pathogenicity of TMUV-JM in chicks, the chicken-origin TMUV-GX displayed high replication competence in multiple tissues and caused tissues histopathological damage. In addition, the replication competence of TMUV-GX in ducklings was comparable to that of TMUV-JM. Our study revealed chicken-origin Cluster 3.2 TMUV exhibits high infectivity in chicks and ducklings, and suggested that chicken-origin Cluster 3.2 TMUV possesses a biological basis for widespread infection of chickens and ducks.
引用
收藏
页数:9
相关论文
共 17 条
  • [1] Pathogenicity of a Jinding duck-origin cluster 2.1 isolate of Tembusu virus in 3-week-old Pekin ducklings
    Feng, Chonglun
    Jin, Meiling
    Yang, Lixin
    Lv, Junfeng
    Qu, Shenghua
    Meng, Runze
    Yang, Baolin
    Wang, Xiaoyan
    Zhang, Dabing
    VETERINARY MICROBIOLOGY, 2020, 251
  • [2] The emergence of a disease caused by a mosquito origin Cluster 3.2 Tembusu virus in chickens in China
    Yan, Dawei
    Li, Xuesong
    Wang, Zhanxin
    Liu, Xingpo
    Dong, Xuan
    Fu, Rui
    Su, Xin
    Xu, Bangfeng
    Teng, Qiaoyang
    Yuan, Chunxiu
    Zhang, Zhifei
    Liu, Qinfang
    Li, Zejun
    VETERINARY MICROBIOLOGY, 2022, 272
  • [3] Pathogenicity of egg-type duck-origin isolate of Tembusu virus in Pekin ducklings
    Liang, Te
    Liu, Xiaoxiao
    Qu, Shenghua
    Lv, Junfeng
    Yang, Lixin
    Zhang, Dabing
    BMC VETERINARY RESEARCH, 2019, 15 (01)
  • [4] Identification and genomic analysis of two duck-origin Tembusu virus strains in southern China
    Li, Linlin
    An, Hejia
    Sun, Minhua
    Dong, Jiawen
    Yuan, Jianfeng
    Hu, Qilin
    VIRUS GENES, 2012, 45 (01) : 105 - 112
  • [5] Identification and genomic analysis of two duck-origin Tembusu virus strains in southern China
    Linlin Li
    Hejia An
    Minhua Sun
    Jiawen Dong
    Jianfeng Yuan
    Qilin Hu
    Virus Genes, 2012, 45 : 105 - 112
  • [6] Pathogenicity of egg-type duck-origin isolate of Tembusu virus in Pekin ducklings
    Te Liang
    Xiaoxiao Liu
    Shenghua Qu
    Junfeng Lv
    Lixin Yang
    Dabing Zhang
    BMC Veterinary Research, 15
  • [7] COMPARATIVE PATHOLOGY OF A CHICKEN-ORIGIN AND 2 DUCK-ORIGIN INFLUENZA-VIRUS ISOLATES IN CHICKENS - THE EFFECT OF ROUTE OF INOCULATION
    SWAYNE, DE
    SLEMONS, RD
    VETERINARY PATHOLOGY, 1994, 31 (02) : 237 - 245
  • [8] A novel goose-origin Tembusu virus exhibits pathogenicity in day-old chicks with evidence of direct contact transmission
    Liu, Min
    Chen, Yao-Yun
    Twu, Ning-Chieh
    Wu, Meng-Chi
    Fang, Zih-Syun
    Dubruel, Alexandre
    Chang, Shih-Chung
    Wu, Ching-Fen
    Lo, Dan-Yuan
    Chen, Hui-Wen
    POULTRY SCIENCE, 2024, 103 (02)
  • [9] Genetic characterization of duck Tembusu virus in Thailand, 2015-2017: Identification of a novel cluster
    Ninvilai, Patchareeporn
    Tunterak, Wikanda
    Oraveerakul, Kanisak
    Amonsin, Alongkorn
    Thontiravong, Aunyaratana
    TRANSBOUNDARY AND EMERGING DISEASES, 2019, 66 (05) : 1982 - 1992
  • [10] Assessing the effect of beta-propiolactone inactivation on the antigenicity and immunogenicity of cluster 2.1 duck Tembusu virus
    Rungprasert, Kanana
    Tunterek, Wikanda
    Areeraksakul, Phornphisut
    Prakairungnamthip, Duangduean
    Sri-in, Chalida
    Techakriengkrai, Navapon
    Banlunara, Wijit
    Jansen, Christine A.
    Nedumpun, Teerawut
    Thontiravong, Aunyaratana
    POULTRY SCIENCE, 2025, 104 (03)