sTREM2 and GFAP Mediated the Association of IGF-1 Signaling Biomarkers with Alzheimer's Disease Pathology

被引：5

作者：

Wang, Zhe ^{[1
]}

Tan, Lin ^{[1
]}

Zong, Yu ^{[1
]}

Ma, Ya-Hui ^{[1
]}

Wang, Zhi-Bo ^{[1
]}

Wang, Hui-Fu ^{[1
,2
]}

Tan, Lan ^{[1
]}

机构：

[1] Qingdao Univ, Qingdao Municipal Hosp, Dept Neurol, 5th Donghai Zhong Rd, Qingdao 266000, Peoples R China

[2] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2023年 / 92卷 / 03期

基金：

中国国家自然科学基金;

关键词：

AD pathology; Alzheimer's disease; GFAP; IGF-1; signaling; IGFBP-2; sTREM2; GROWTH-FACTOR-I; INSULIN-RESISTANCE;

D O I：

10.3233/JAD-220725

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Defects in insulin-like growth factor 1 (IGF-1) signaling is a key contributor to Alzheimer's disease (AD). However, the mechanism of how IGF-1 signaling relates to AD remained unclear. Here, we investigated the association of IGF-1 signaling associated biomarkers with AD pathology, sTREM2, and GFAP. Finally, insulin-like growth factor binding protein 2 (IGFBP-2) was associated with AD pathology, and the association was partly medicated by sTREM2 (A beta(42), beta = 0.794, p = 0.016; T-tau, beta = 0.291, p < 0.001; P-tau(181), beta = 0.031, p < 0.001) and GFAP (T-tau, beta = 0.427, p < 0.001; P-tau(181), beta = 0.044, p < 0.001). It suggested that sTREM2 and GFAP mediated the relationship between IGF-1 signaling and AD pathology.

引用

页码：791 / 797

页数：7

共 25 条

[1] Insulin-Like Growth Factor Binding Protein 2 Is Associated With Biomarkers of Alzheimer's Disease Pathology and Shows Differential Expression in Transgenic Mice [J].

Bonham, Luke W. ;

Geier, Ethan G. ;

Steele, Natasha Z. R. ;

Holland, Dominic ;

Miller, Bruce L. ;

Dale, Anders M. ;

Desikan, Rahul S. ;

Yokoyama, Jennifer S. .

FRONTIERS IN NEUROSCIENCE, 2018, 12

[2] Serum insulin-like growth factor I regulates brain amyloid-levels [J].

Carro, E ;

Trejo, JL ;

Gomez-Isla, T ;

LeRoith, D ;

Torres-Aleman, I .

NATURE MEDICINE, 2002, 8 (12) :1390-1397

[3] Astrocyte Biomarkers in Alzheimer's Disease [J].

Carter, Stephen F. ;

Herholz, Karl ;

Rosa-Neto, Pedro ;

Pellerin, Luc ;

Nordberg, Agneta ;

Zimmer, Eduardo R. .

TRENDS IN MOLECULAR MEDICINE, 2019, 25 (02) :77-95

[4] Insulin action in the brain: cell types, circuits, and diseases [J].

Chen, Wenqiang ;

Cai, Weikang ;

Hoover, Benjamin ;

Kahn, C. Ronald .

TRENDS IN NEUROSCIENCES, 2022, 45 (05) :384-400

[5]

Diehl T, 2017, TRANSL RES, V183, P26, DOI [10.1016/j.trsl.2016.12.005, 10.3389/fnins.2018.00830]

[6] Plasma biomarkers of astrocytic and neuronal dysfunction in early- and late-onset Alzheimer's [J].

Elahi, Fanny M. ;

Casaletto, Kaitlin B. ;

La Joiel, Renaud ;

Walters, Samantha M. ;

Harvey, Danielle ;

Wolf, Amy ;

Edwards, Lauren ;

Rivera-Contreras, Wilfredo ;

Karydas, Anna ;

Cobigo, Yann ;

Rosen, Howard J. ;

DeCarli, Charles ;

Miller, Bruce L. ;

Rabinovici, Gil D. ;

Kramer, Joel H. .

ALZHEIMERS & DEMENTIA, 2020, 16 (04) :681-695

[7] NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease [J].

Jack, Clifford R., Jr. ;

Bennett, David A. ;

Blennow, Kaj ;

Carrillo, Maria C. ;

Dunn, Billy ;

Haeberlein, Samantha Budd ;

Holtzman, David M. ;

Jagust, William ;

Jessen, Frank ;

Karlawish, Jason ;

Liu, Enchi ;

Luis Molinuevo, Jose ;

Montine, Thomas ;

Phelps, Creighton ;

Rankin, Katherine P. ;

Rowe, Christopher C. ;

Scheltens, Philip ;

Siemers, Eric ;

Snyder, Heather M. ;

Sperling, Reisa ;

Elliott, Cerise ;

Masliah, Eliezer ;

Ryan, Laurie ;

Silverberg, Nina .

ALZHEIMERS & DEMENTIA, 2018, 14 (04) :535-562

[8] Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease [J].

Jiang, Teng ;

Tan, Lan ;

Zhu, Xi-Chen ;

Zhang, Qiao-Quan ;

Cao, Lei ;

Tan, Meng-Shan ;

Gus, Li-Ze ;

Wang, Hui-Fu ;

Ding, Zheng-Zheng ;

Zhang, Ying-Dong ;

Yu, Jin-Tai .

NEUROPSYCHOPHARMACOLOGY, 2014, 39 (13) :2949-2962

[9] Variant of TREM2 Associated with the Risk of Alzheimer's Disease [J].

Jonsson, Thorlakur ;

Stefansson, Hreinn ;

Steinberg, Stacy ;

Jonsdottir, Ingileif ;

Jonsson, Palmi V. ;

Snaedal, Jon ;

Bjornsson, Sigurbjorn ;

Huttenlocher, Johanna ;

Levey, Allan I. ;

Lah, James J. ;

Rujescu, Dan ;

Hampel, Harald ;

Giegling, Ina ;

Andreassen, Ole A. ;

Engedal, Knut ;

Ulstein, Ingun ;

Djurovic, Srdjan ;

Ibrahim-Verbaas, Carla ;

Hofman, Albert ;

Ikram, M. Arfan ;

van Duijn, Cornelia M. ;

Thorsteinsdottir, Unnur ;

Kong, Augustine ;

Stefansson, Kari .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (02) :107-116

[10] TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis [J].

Kleinberger, Gernot ;

Yamanishi, Yoshinori ;

Suarez-Calvet, Marc ;

Czirr, Eva ;

Lohmann, Ebba ;

Cuyvers, Elise ;

Struyfs, Hanne ;

Pettkus, Nadine ;

Wenninger-Weinzierl, Andrea ;

Mazaheri, Fargol ;

Tahirovic, Sabina ;

Lleo, Alberto ;

Alcolea, Daniel ;

Fortea, Juan ;

Willem, Michael ;

Lammich, Sven ;

Molinuevo, Jose L. ;

Sanchez-Valle, Raquel ;

Antonell, Anna ;

Ramirez, Alfredo ;

Heneka, Michael T. ;

Sleegers, Kristel ;

van der Zee, Julie ;

Martin, Jean-Jacques ;

Engelborghs, Sebastiaan ;

Demirtas-Tatlidede, Asli ;

Zetterberg, Henrik ;

Van Broeckhoven, Christine ;

Gurvit, Hakan ;

Wyss-Coray, Tony ;

Hardy, John ;

Colonna, Marco ;

Haass, Christian .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (243)

← 1 2 3 →