(Z)-2′-((Adamantan-1-yl)thio)-1,1′-dimethyl-2′,3′-dihydro-[2,4′-biimidazolylidene]-4,5,5′(1H,1′H,3H)-trione

被引：0

作者：

Burmistrov, Vladimir ^{[1
,2
]}

Mokhov, Vladimir ^{[1
]}

Fayzullin, Robert R. ^{[3
]}

Butov, Gennady M. ^{[1
,2
]}

机构：

[1] Volgograd State Tech Univ, Dept Technol Organ & Petrochem Synth, Volgograd 400005, Russia

[2] Volgograd State Tech Univ, Volzhsky Polytech Inst, Dept Chem Technol & Equipment Chem Ind, Branch, Volzhsky 404121, Russia

[3] Russian Acad Sci, Arbuzov Inst Organ & Phys Chem, FRC Kazan Sci Ctr, 8 Arbuzov St, Kazan 420088, Russia

来源：

MOLBANK | 2023年 / 2023卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

adamantane; thiohydantoin; by-product; X-ray structure; ANDROGEN RECEPTOR; 1,3-DEHYDROADAMANTANE; HYDANTOINS; 2-THIOHYDANTOIN; ADAMANTYLATION; ANTIANDROGEN; CANCER;

D O I：

10.3390/M1585

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound, (Z)-2 '-((adamantan-1-yl)thio)-1,1 '-dimethyl-2 ',3 '-dihydro-[2,4 '-biimidazolylidene]-4,5,5 '(1H,1 ' H,3H)-trione, was found to be a by-product of the reaction of 1,3-dehydroadamantane with 3-methyl-2-thioxoimidazolidin-4-one and characterized via single-crystal X-ray diffraction.

引用

页数：6

共 32 条

[1] Synthesis of new thiohydantoin derivatives under phase transfer catalysis [J].

Abou El-Regal, M. K. ;

Abdalha, A. A. ;

El-Kassaby, M. A. ;

Ali, A. T. .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2007, 182 (04) :845-851

[2] 5-(pyridylmethylidene)-substituted 2-thiohydantoins and their complexes with CuII, NiII, and CoII:: synthesis, electrochemical study, and adsorption on the cystamine-modified gold surface [J].

Beloglazkina, E. K. ;

Majouga, A. G. ;

Yudin, L. V. ;

Frolova, N. A. ;

Zyk, N. V. ;

Dozhikova, V. D. ;

Moiseeva, A. A. ;

Rakhimov, R. D. ;

Butin, K. P. .

RUSSIAN CHEMICAL BULLETIN, 2006, 55 (06) :1015-1027

[3] SYNTHESIS AND IMMUNOMODULATING ACTIVITY OF 1-AMINO-2-THIOHYDANTOIN DERIVATIVES [J].

BLANC, M ;

CUSSAC, M ;

BOUCHERLE, A ;

LECLERC, G .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (08) :839-843

[4] Adamantyl Isothiocyanates as Mutant p53 Rescuing Agents and Their Structure-Activity Relationships [J].

Burmistrov, Vladimir ;

Saxena, Rahul ;

Pitushkin, Dmitry ;

Butov, Gennady M. ;

Chung, Fung-Lung ;

Aggarwal, Monika .

JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (10) :6621-6633

[5] Synthesis of 3-adamantylated hydantoins and their 2-thio(seleno) analogs [J].

Burmistrov, Vladimir V. ;

Pitushkin, Dmitry A. ;

Vasipov, Vladimir V. ;

D'yachenko, Vladimir S. ;

Butov, Gennady M. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2019, 55 (07) :619-622

[6] Reactions of 1,3-dehydroadamantane with inorganic oxygen-free acids [J].

Butov, G. M. ;

Mokhov, V. M. ;

Burmistrov, V. V. ;

Saad, K. R. ;

Pitushkin, D. A. .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 50 (09) :1276-1278

[7] Reaction of 1,3-dehydroadamantane with dicarboxylic acid imides [J].

Butov, G. M. ;

Mokhov, V. M. .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 49 (09) :1403-1404

[8] Adamantylation of Azoles by 1,3-Dehydroadamantane: I. N-Adamantylation of Imidazoles by 1,3-Dehydroadamantane [J].

Butov, G. M. ;

Mokhov, V. M. ;

Parshin, G. Yu. ;

Panyushkina, O. A. .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 45 (11) :1732-1733

[9] STRUCTURE-ACTIVITY STUDY ON ANTICONVULSANT (THIO) HYDANTOINS USING MOLECULAR CONNECTIVITY INDEXES [J].

DANG, P ;

MADAN, AK .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1994, 34 (05) :1162-1166

[10] A new and convenient synthesis of some substituted thiohydantoins [J].

Dürüst, Y ;

Nohut, F .

SYNTHETIC COMMUNICATIONS, 1999, 29 (11) :1997-2005

← 1 2 3 4 →