Development of gold-coated magnetic nanoparticles as a theranostic agent for magnetic hyperthermia and CT imaging applications

被引：10

作者：

Tonthat, Loi ^{[1
]}

Kimura, Mone ^{[2
]}

Ogawa, Tomoyuki ^{[1
]}

Kitamura, Narufumi ^{[2
]}

Kobayashi, Yoshio ^{[3
]}

Gonda, Kohsuke ^{[2
,4
]}

Yabukami, Shin ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Engn, Sendai 9808579, Japan

[2] Tohoku Univ, Grad Sch Med, Sendai 9808575, Japan

[3] Ibaraki Univ, Grad Sch Sci & Engn, Ibaraki 3168511, Japan

[4] Tohoku Univ, Int Ctr Synchrotron Radiat Innovat Smart SRIS, Sendai 9808577, Japan

来源：

AIP ADVANCES | 2023年 / 13卷 / 02期

基金：

日本学术振兴会;

关键词：

IRON-OXIDE NANOPARTICLES; ABSORPTION RATE; FIELD; PARTICLES;

D O I：

10.1063/9.0000592

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this study, we aim to develop gold-coated Fe3O4 nanoparticles (Fe3O4@Au NPs) as theranostic agents for magnetic hyperthermia and CT imaging applications. The Fe3O4 NPs were synthesized via thermal decomposition method, and the gold was then deposited onto the surface of Fe3O4 NPs by reducing gold acetate at 190 ?. The average sizes of Fe3O4 and Fe3O4@Au NPs were 5.2 nm and 6.1 nm, respectively, which are effectively removed by the kidneys. The magnetization of Fe3O4@Au NPs (9.7 emu/g-Fe3O4) at 300 K was much smaller than that of Fe3O4 NPs (52.4 emu/g-Fe3O4). The heating efficiency of Fe3O4@Au NPs in water was sufficient to treat the tumor at 43-45 ?, and their high CT value of 851 HU was obtained. The synthesized ultrasmall Fe3O4@Au NPs showed great promise as a potential theranostic agent for magnetic hyperthermia and CT imaging applications.

引用

页数：5

共 34 条

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